(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Base Information

Chemical Name:(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
CAS No.:914805-33-7
Molecular Formula:C₄₂H₅₆N₂O₁₀
Molecular Weight:748.914
Hs Code.:

Synonyms:(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Suppliers and Price of (R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Shield1
2.5mg
$ 640.00

DC Chemicals
Shield-1 99%
250 mg
$ 2100.00

DC Chemicals
Shield-1 99%
100 mg
$ 1200.00

ChemScene
Shield-1 99.62%
50mg
$ 2700.00

ChemScene
Shield-1 99.62%
100mg
$ 3850.00

ChemScene
Shield-1 99.62%
5mg
$ 450.00

ChemScene
Shield-1 99.62%
1mg
$ 200.00

ChemScene
Shield-1 99.62%
25mg
$ 1600.00

ChemScene
Shield-1 99.62%
10mg
$ 730.00

Biorbyt Ltd
Shield-1 >0.99
250 mg
$ 1802.00

Total 12 raw suppliers

Chemical Property of (R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Chemical Property:

Melting Point:54-55o C
Boiling Point:837.6±65.0 °C(Predicted)
Density:1.168±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Shield1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Shield 1, an AKT inhibitor, potently inhibits proliferation as well as induces apoptosis in prostate cancer cell lines.

Technology Process of (R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

There total 8 articles about (R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 195202-09-6
(S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylic acid

: 1374119-33-1
(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)-propan-1-ol

: 914805-33-7
(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 3h; Reagent/catalyst;
DOI:10.1021/acs.joc.8b00698

Reference yield:

: 4043-87-2,83680-83-5
pipecolic Acid

: 914805-33-7
(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 0.08 h

2: sodium hydrogencarbonate / 1,4-dioxane / 22 h / Reflux

3: dmap; diisopropyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C

With dmap; sodium hydrogencarbonate; diisopropyl-carbodiimide; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/acs.joc.8b00698

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 914805-33-7
(R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / ethanol; water / 0 °C

2: palladium on activated carbon; ammonium bicarbonate / methanol / 3 h / Reflux

3: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; borane dimethyl sulfide complex / tetrahydrofuran / 1.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

5: dmap; diisopropyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C

With dmap; borane dimethyl sulfide complex; palladium on activated carbon; ammonium bicarbonate; potassium carbonate; potassium hydroxide; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: |Aldol Condensation / 3: |Corey-Bakshi-Shibata Reduction;
DOI:10.1021/acs.joc.8b00698