5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID

Base Information

• Chemical Name: 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID
• CAS No.: 88699-88-1
• Molecular Formula: C12H11F3O3
• Molecular Weight: 260.21
• Hs Code.: 2918300090
• Mol file: 88699-88-1.mol

Synonyms:5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID

Chemical Property of 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID

Chemical Property:

• Vapor Pressure: 5.06E-07mmHg at 25°C
• Boiling Point: 397.2°C at 760 mmHg
• Flash Point: 194°C
• PSA: 54.37000
• Density: 1.31g/cm³
• LogP: 3.14300

Purity/Quality:

98% ^*data from raw suppliers

5-Oxo-5-(4-trifluoromethylphenyl)valericacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID

There total 5 articles about 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

cis-2-(4-(trifluoromethyl)phenyl)cyclohexylamine → 5-oxo-5-(4-(trifluoromethyl)phenyl)pentanoic acid (88699-88-1)

Guidance literature:

With rose bengal; oxygen; In 1,4-dioxane; at 25 ℃; for 24h; Irradiation;

DOI:10.1002/chem.201604440

Reference yield:

glutaric anhydride, (108-55-4) + p-trifluoromethylphenyl bromide (402-43-7) → 5-oxo-5-(4-(trifluoromethyl)phenyl)pentanoic acid (88699-88-1)

Guidance literature:

p-trifluoromethylphenyl bromide; With iodine; magnesium; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;

glutaric anhydride,; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.201806057

Reference yield:

glutaric anhydride, (108-55-4) + 4-(trifluoromethyl)phenylmagnesium bromide (402-51-7) → 5-oxo-5-(4-(trifluoromethyl)phenyl)pentanoic acid (88699-88-1)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c5ob02622a

upstream raw materials:

glutaric anhydride,

4-(trifluoromethyl)phenylmagnesium bromide

p-trifluoromethylphenyl bromide

Downstream raw materials:

6-(trifluoromethyl)-3,4-dihydronaphthalen-1(2H)-one

5-(4-(trifluoromethyl)phenyl)hex-5-enoic acid

Refernces

• 1、 Zhao, Mengmeng,Lu, Bin,Ding, Guangni,Ren, Kai,Xie, Xiaomin,Zhang, Zhaoguo. "Ru-catalyzed asymmetric hydrogenation of δ-keto Weinreb amides: Enantioselective synthesis of (+)-Centrolobine". . p. 2723 - 2730. Retrieved 2016/03/05.
• 2、 -. "NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF". Page/Page column 44. . Retrieved 2012/01/14.