402-51-7

Basic information

• Product Name: 4-TRIFLUOROMETHYLPHENYLMAGNESIUMBROMIDE
• Synonyms: 4-TRIFLUOROMETHYLPHENYLMAGNESIUMBROMIDE;(4-(Trifluoromethyl)phenyl)magnesium bromide, 0.50 M in THF;(4-(Trifluoromethyl)phenyl)magnesium bromide, 0.50 M in 2-MeTHF
• CAS NO: 402-51-7
• Molecular Formula: Br*C₇H₄F₃*Mg
• Molecular Weight: 249.3108696
• Mol File: 402-51-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 156.5°C
• Appearance: /
• CAS DataBase Reference: 4-TRIFLUOROMETHYLPHENYLMAGNESIUMBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TRIFLUOROMETHYLPHENYLMAGNESIUMBROMIDE(402-51-7)
• EPA Substance Registry System: 4-TRIFLUOROMETHYLPHENYLMAGNESIUMBROMIDE(402-51-7)

Safety Data

• Hazardous Substances Data: 402-51-7(Hazardous Substances Data)

Usage

General Description

4-Trifluoromethylphenylmagnesiumbromide is a chemical compound that consists of a magnesium atom bonded to a phenyl group with a trifluoromethyl substituent and a bromine atom. It is commonly used as a reagent in organic synthesis, particularly in the formation of carbon-carbon bonds through Grignard reactions. 4-TRIFLUOROMETHYLPHENYLMAGNESIUMBROMIDE is a strong nucleophile and can undergo reactions with various electrophiles, such as carbonyl compounds, to form new carbon-carbon bonds. It is also employed in the synthesis of pharmaceuticals and agrochemicals, making it an important intermediate in the production of various organic compounds. However, it should be handled carefully due to its reactivity and potential for hazardous reactions.

InChI:InChI=1/C7H4F3.BrH.Mg/c8-7(9,10)6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1/rC7H4BrF3Mg/c8-12-6-3-1-5(2-4-6)7(9,10)11/h1-4H

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 7439-95-4 magnesium 

Downstream Products

• 22707-48-8 p-Trifluormethylphenyl-tert.butyl-methyl-carbinol 
• 395-23-3 phenyl(4-(trifluoromethyl)phenyl)methanol 
• 1813-97-4 1-allyl-4-(trifluoromethyl)benzene 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 67346-89-8 (Z)-1-(p-trifluoromethyl)phenylpentafluoropropene 
• 67366-58-9 (E)-1-(p-trifluoromethyl)phenylpentafluoropropene 
• 783-79-9 1,1,1-trifluoro-2-(4-(trifluoromethyl)phenyl)propan-2-ol 
• 137995-60-9 2-(1-Benzyl-piperidin-4-yl)-1-(4-trifluoromethyl-phenyl)-ethanol 
• 39768-86-0 (4-fluorophenyl)(4-(trifluoromethyl)phenyl)methanol 
• 91993-97-4 (4R,5R)-2,4,7-Trimethyl-5-(4-trifluoromethyl-phenyl)-4,5-dihydro-1H-azepine-3,6-dicarboxylic acid dimethyl ester 
• 91993-98-5 (4S,5R)-2,4,7-Trimethyl-5-(4-trifluoromethyl-phenyl)-4,5-dihydro-1H-azepine-3,6-dicarboxylic acid dimethyl ester 
• 1026243-21-9 (R)-3-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-1-(4-trifluoromethyl-phenyl)-cyclohexanol 
• 29480-13-5 1-(4-(trifluoromethyl)phenyl)cyclohexanol 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 

Relevant articles and documents

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES

The present disclosure relates to novel compounds, pharmaceutical compositions containing the compounds and methods of using the compounds and pharmaceutical compositions for treating neurodegerative diseases, including Alzheimer's disease and cognitive decline. Methods for inhibiting synapse number decline or membrane trafficking abnormalities associated with exposure of a neuronal cell to Abeta species are also disclosed.

Palladium-catalyzed aerobic oxidative double allylic C-H oxygenation of alkenes: A novel and straightforward route to α,β-unsaturated esters

A mild tandem oxidative functionalization of allyl aromatic hydrocarbons was accomplished using the catalytic system of Pd(OAc)2/DMA under 1 atm O2. The green twofold C-O bond formation involving double allylic C-H oxygenation unlocks opportunities for markedly different synthetic strategies. Moreover, the reaction affords aryl α,β-unsaturated esters directly from readily available terminal olefins in moderate to good yields with excellent chemo- and stereoselectivities.