N5-[(2,4-Dimethoxyphenyl)methyl]-N2-[(benzyloxy)carbonyl]-L-glutamine methyl ester

Base Information

• Chemical Name: N5-[(2,4-Dimethoxyphenyl)methyl]-N2-[(benzyloxy)carbonyl]-L-glutamine methyl ester
• CAS No.: 31874-48-3
• Molecular Formula: C₂₃H₂₈N₂O₇
• Molecular Weight: 444.485
• Mol file: 31874-48-3.mol

Synonyms:N5-[(2,4-Dimethoxyphenyl)methyl]-N2-[(benzyloxy)carbonyl]-L-glutamine methyl ester

Chemical Property of N5-[(2,4-Dimethoxyphenyl)methyl]-N2-[(benzyloxy)carbonyl]-L-glutamine methyl ester

Chemical Property:

• Melting Point: 125 °C
• PSA: 112.19000
• LogP: 3.35000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N5-[(2,4-Dimethoxyphenyl)methyl]-N2-[(benzyloxy)carbonyl]-L-glutamine methyl ester

There total 1 articles about N5-[(2,4-Dimethoxyphenyl)methyl]-N2-[(benzyloxy)carbonyl]-L-glutamine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethoxybenzaldoxime (31874-34-7) + Z-L-GluOMe (5672-83-3) → (S)-2-Benzyloxycarbonylamino-4-(2,4-dimethoxy-benzylcarbamoyl)-butyric acid methyl ester (31874-48-3)

Guidance literature:

Multistep reaction; (i) Na, (ii) /BRN= 2567599/;

DOI:10.1021/jo00824a025

Reference yield:

(S)-2-Benzyloxycarbonylamino-4-(2,4-dimethoxy-benzylcarbamoyl)-butyric acid methyl ester (31874-48-3) → Nγ-(2,4-Dimethoxybenzyl)-L-glutamin

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: H₂ / Pd-C

With sodium hydroxide; hydrogen; palladium on activated charcoal;

DOI:10.1021/jo00824a025

Reference yield:

(S)-2-Benzyloxycarbonylamino-4-(2,4-dimethoxy-benzylcarbamoyl)-butyric acid methyl ester (31874-48-3) → Z-Gln(Dmb)-OH (31874-51-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jo00824a025

upstream raw materials:

2,4-dimethoxybenzaldoxime

Z-L-GluOMe

Downstream raw materials:

Z-Gln(Dmb)-OH

Z-Gln(Dmb)-ONp