(R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

Base Information

Chemical Name:(R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one
CAS No.:948893-91-2
Molecular Formula:C₂₄H₃₀N₄O₃Si
Molecular Weight:450.613
Hs Code.:

Synonyms:(R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

Suppliers and Price of (R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of (R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

There total 6 articles about (R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 948893-91-2
(R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

Guidance literature:: With sodium azide; sodium iodide; In water; N,N-dimethyl-formamide;

Reference yield:

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

: 948893-91-2
(R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0.08 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium iodide; sodium azide / N,N-dimethyl-formamide; water / 40 h / 80 °C

With 2,6-dimethylpyridine; sodium azide; sodium iodide; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 93609-84-8
5-acetyl-8-benzyloxy-1H-quinolin-2-one

: 948893-91-2
(R)-5-(2-azido-1-((tert-butyldimethylsilyl)oxy)ethyl)-8-(benzyloxy)quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra-N-butylammonium tribromide / tetrahydrofuran; methanol / 20 °C

2.1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 4 h / -20 °C / Inert atmosphere

2.2: 0.33 h / -20 - 20 °C

2.3: 18 h / 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 0.08 h / 0 °C

3.2: 0 - 20 °C

4.1: sodium iodide; sodium azide / N,N-dimethyl-formamide; water / 40 h / 80 °C

With 2,6-dimethylpyridine; sodium azide; dimethylsulfide borane complex; tetra-N-butylammonium tribromide; sodium iodide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;