(1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Base Information

Chemical Name:(1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
CAS No.:1415970-74-9
Molecular Formula:C₄₀H₅₇N₃O₆
Molecular Weight:675.909
Hs Code.:

Synonyms:(1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

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Chemical Property of (1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

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Technology Process of (1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

There total 16 articles about (1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1415971-12-8
(R)-5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one hydrochloride

: 1445205-08-2
C₂₉H₄₅NO₄

: 1415970-74-9
(1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Guidance literature:: (R)-5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one hydrochloride; C₂₉H₄₅NO₄; With triethylamine; In methanol; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; In methanol; at 20 ℃; for 72h;

Reference yield: 16.0%

: 1415971-12-8
(R)-5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one hydrochloride

: 1415971-17-3
(1-(10-oxodecyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

: 1415970-74-9
(1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Guidance literature:: (R)-5-(2-amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one hydrochloride; (1-(10-oxodecyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; With triethylamine; In methanol; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; In methanol; at 20 ℃; for 72h;

Reference yield:

: 93609-84-8
5-acetyl-8-benzyloxy-1H-quinolin-2-one

: 1415970-74-9
(1-(9-((2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino)nonyl)piperidin-4-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetra-N-butylammonium tribromide / tetrahydrofuran; methanol / 20 °C

2.1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; tetrahydrofuran / 4 h / -20 °C / Inert atmosphere

2.2: 0.33 h / -20 - 20 °C

2.3: 18 h / 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 0.08 h / 0 °C

3.2: 0 - 20 °C

4.1: sodium iodide; sodium azide / N,N-dimethyl-formamide; water / 40 h / 80 °C

5.1: palladium 10% on activated carbon / methanol / 1 h / 80 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 20 °C

7.1: triethylamine / methanol / 1 h / 20 °C

7.2: 72 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium azide; dimethylsulfide borane complex; tetra-N-butylammonium tribromide; triethylamine; sodium iodide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;