4,6-Difluoro-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene

Base Information

Chemical Name:4,6-Difluoro-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene
CAS No.:939760-68-6
Molecular Formula:C10H8F2O
Molecular Weight:182.17
Hs Code.:
DSSTox Substance ID:DTXSID40585780
Mol file:939760-68-6.mol

Synonyms:4,6-Difluoro-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene;939760-68-6;4,6-Difluoro-1A,2,3,7B-Tetrahydro-1-Oxa-Cyclopropa[A]Naphthalene;DTXSID40585780;AKOS005138029;J-514154

Suppliers and Price of 4,6-Difluoro-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4,6-DIFLUORO-1A,2,3,7B-TETRAHYDRO-1-OXA-CYCLOPROPA[A]NAPHTHALENE 95.00%
5MG
$ 505.84

Total 4 raw suppliers

Chemical Property of 4,6-Difluoro-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene

Chemical Property:

Vapor Pressure:0.191mmHg at 25°C
Boiling Point:217.9°C at 760 mmHg
Flash Point:92.3°C
PSA：12.53000
Density:1.354g/cm³
LogP:2.35090
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:182.05432120
Heavy Atom Count:13
Complexity:221

Purity/Quality:

99%+ ^*data from raw suppliers

4,6-DIFLUORO-1A,2,3,7B-TETRAHYDRO-1-OXA-CYCLOPROPA[A]NAPHTHALENE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C=C(C=C2F)F)C3C1O3

Technology Process of 4,6-Difluoro-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene

There total 8 articles about 4,6-Difluoro-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939760-86-8
6,8-Difluoro-1,2-dihydro-naphthalene

: 939760-68-6
4,6-Difluoro-1a,2,3,7b-tetrahydro-1-oxa-cyclopropa[a]naphthalene

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 - 20 ℃;
DOI:10.1016/0957-4166(95)00180-W

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 939760-68-6
4,6-Difluoro-1a,2,3,7b-tetrahydro-1-oxa-cyclopropa[a]naphthalene

Guidance literature:: Multi-step reaction with 8 steps

1: (Ph)2PCl₂, Et₃N / dimethylformamide / 6 h / 85 °C

2: H₂ / 10percent Pd/C / ethyl acetate / 3102.9 Torr

3: 6N aq. H₂CrO₄ / acetone / 20 °C

4: oxalyl chloride, DMF / CH₂Cl₂ / 20 °C

5: AlCl₃ / CS₂ / 40 °C

6: NaBH₄ / methanol / 0 °C

7: p-TsOH / benzene / 80 °C

8: m-chloroperbenzoic acid / CHCl₃ / 0 - 20 °C

With sodium tetrahydroborate; aluminium trichloride; oxalyl dichloride; dichlorodiphenylphosphine; hydrogen; chromic acid; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; carbon disulfide; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/0957-4166(95)00180-W

Reference yield:

: 4-(2,4-Difluoro-phenyl)-but-3-yn-1-ol

: 939760-68-6
4,6-Difluoro-1a,2,3,7b-tetrahydro-1-oxa-cyclopropa[a]naphthalene

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 3102.9 Torr

2: 6N aq. H₂CrO₄ / acetone / 20 °C

3: oxalyl chloride, DMF / CH₂Cl₂ / 20 °C

4: AlCl₃ / CS₂ / 40 °C

5: NaBH₄ / methanol / 0 °C

6: p-TsOH / benzene / 80 °C

7: m-chloroperbenzoic acid / CHCl₃ / 0 - 20 °C

With sodium tetrahydroborate; aluminium trichloride; oxalyl dichloride; hydrogen; chromic acid; toluene-4-sulfonic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In methanol; carbon disulfide; dichloromethane; chloroform; ethyl acetate; acetone; benzene;
DOI:10.1016/0957-4166(95)00180-W