GRISEOFULVIN-D3

Base Information

• Chemical Name: GRISEOFULVIN-D3
• CAS No.: 1279033-22-5
• Molecular Formula: C17H14ClD3O6
• Molecular Weight: 355.78
• Mol file: 1279033-22-5.mol

Synonyms:GRISEOFULVIN-D3;(1'S,6'R)-7-Chloro-2',6-dimethoxy-4-(methoxy-d3)-6'-methyl-spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione;Amudane-d3;Fulcin-d3;Grisovin-d3;Spirofulvin-d3;Sporostatin-d3;Xuanjing-d3

Chemical Property of GRISEOFULVIN-D3

Chemical Property:

• Melting Point: 2200C

Purity/Quality:

98%2H ^*data from raw suppliers

Griseofulvin-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Griseofulvin-d3 is an antifungal drug and used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum Griseofulvin-d3 is the labeled analogue of Griseofulvin (G787500), an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants

Technology Process of GRISEOFULVIN-D3

There total 1 articles about GRISEOFULVIN-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-chloro-6'-methyl-cyclohex-2'-en-4'-one) (26881-56-1) + d(4)-methanol (811-98-3) → (2S,6'R)-7-chloro-4,6-dimethoxy-2'-(methoxy-d3)-6'-methyl-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione (1279033-22-5)

Guidance literature:

(6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-chloro-6'-methyl-cyclohex-2'-en-4'-one); d⁽⁴⁾-methanol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 22 ℃; for 72h; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 22 ℃; for 53h; Reflux;

DOI:10.1016/j.ejmech.2016.03.071

upstream raw materials:

(6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-one)-2-spiro-1'-(2'-chloro-6'-methyl-cyclohex-2'-en-4'-one)

d⁽⁴⁾-methanol

Refernces