5-BroMo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine

Base Information

• Chemical Name: 5-BroMo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine
• CAS No.: 1369509-72-7
• Molecular Formula: C₁₁H₁₁BrIN₃O
• Molecular Weight: 408.036
• Hs Code.: 2934999090
• Mol file: 1369509-72-7.mol

Synonyms:5-BroMo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine

Chemical Property of 5-BroMo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine

Chemical Property:

• Boiling Point: 502.3±50.0 °C(Predicted)
• PKA: 2.95±0.30(Predicted)
• PSA: 39.94000
• Density: 2.25±0.1 g/cm3(Predicted)
• LogP: 3.49750

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine

There total 4 articles about 5-BroMo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3,4-dihydro-2H-pyran (110-87-2) + 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine (1357947-08-0) → 5-bromo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine (1369509-72-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 24h;

DOI:10.1016/j.bmcl.2015.09.052

Reference yield:

2-bromo-4-methyl-5-nitropyridine (23056-47-5) → 5-bromo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine (1369509-72-7)

Guidance literature:

Multi-step reaction with 4 steps

1: zinc; ammonium chloride / ethanol; water / 20 °C

2: sodium nitrite; acetic acid / 0 - 20 °C

3: N-iodo-succinimide / N,N-dimethyl-formamide / 0 - 20 °C

4: toluene-4-sulfonic acid / dichloromethane / 24 h

With N-iodo-succinimide; ammonium chloride; toluene-4-sulfonic acid; acetic acid; zinc; sodium nitrite; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2015.09.052

Reference yield:

6-bromo-4-methyl-pyridin-3-ylamine (156118-16-0) → 5-bromo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine (1369509-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite; acetic acid / 0 - 20 °C

2: N-iodo-succinimide / N,N-dimethyl-formamide / 0 - 20 °C

3: toluene-4-sulfonic acid / dichloromethane / 24 h

With N-iodo-succinimide; toluene-4-sulfonic acid; acetic acid; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2015.09.052

upstream raw materials:

2-bromo-4-methyl-5-nitropyridine

6-bromo-4-methyl-pyridin-3-ylamine

5-bromo-1H-pyrazolo[3,4m-c]pyridine

3,4-dihydro-2H-pyran

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