N1-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine

Base Information

Chemical Name:N1-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine
CAS No.:1453199-38-6
Molecular Formula:C₂₁H₂₂ClN₇O
Molecular Weight:0
Hs Code.:
Mol file:1453199-38-6.mol

Synonyms:N1-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine

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Chemical Property of N1-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine

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Technology Process of N1-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine

There total 7 articles about N1-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1453199-37-5
5-chloro-N-{4-[(dimethylamino)methyl]-2-methoxy-5-nitrophenyl}-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-amine

: 1453199-38-6
N₁-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; zinc(II) iodide; In methanol; ethyl acetate; at 20 ℃; for 3h;
DOI:10.1021/jm400822z

Reference yield:

: 457099-66-0
1-(3-methoxy-4-nitrophenyl)-N,N-dimethylmethanamine

: 1453199-38-6
N₁-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

2: guanidine nitrate; sulfuric acid / 2 h / 0 - 10 °C

3: toluene-4-sulfonic acid / 2 h / 160 °C / Inert atmosphere

4: hydrogen; palladium 10% on activated carbon; zinc(II) iodide / methanol; ethyl acetate / 3 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; guanidine nitrate; hydrogen; toluene-4-sulfonic acid; zinc(II) iodide; In methanol; ethyl acetate;
DOI:10.1021/jm400822z

Reference yield:

: 927672-81-9
4-[(dimethylamino)methyl]-2-methoxyaniline

: 1453199-38-6
N₁-(5-chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)-4-[(dimethylamino)methyl]-6-methoxybenzene-1,3-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: guanidine nitrate; sulfuric acid / 2 h / 0 - 10 °C

2: toluene-4-sulfonic acid / 2 h / 160 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon; zinc(II) iodide / methanol; ethyl acetate / 3 h / 20 °C

With sulfuric acid; palladium 10% on activated carbon; guanidine nitrate; hydrogen; toluene-4-sulfonic acid; zinc(II) iodide; In methanol; ethyl acetate;
DOI:10.1021/jm400822z