[R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Base Information

• Chemical Name: [R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one
• CAS No.: 21414-43-7
• Molecular Formula: C₂₁H₂₁NO₆
• Molecular Weight: 383.401
• Mol file: 21414-43-7.mol

Synonyms:[R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Chemical Property of [R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one

Chemical Property:

• PSA: 66.46000
• LogP: 2.81110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one

There total 28 articles about [R,(-)]-6-[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]furo[3,4-e]-1,3-benzodioxol-8(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

carbon monoxide (201230-82-2) + erythro-1-(2-bromo-3,4-(methylenedioxy)-α-hydroxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline → (+/-)-corlumine (485-51-8,524-46-9,21414-43-7,30770-75-3,38184-69-9,64397-12-2,79082-64-7)

Guidance literature:

With chloro-trimethyl-silane; Pd(PPh₃)(OAc)2; potassium carbonate; In toluene; at 140 ℃; for 24h;

DOI:10.1021/jo982451w

Reference yield: 60.0%

carbon monoxide (201230-82-2) + 1-(2-bromo-3,4-(methylenedioxy)-α-hydroxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline → (+/-)-adlumine (485-51-8,524-46-9,21414-43-7,30770-75-3,38184-69-9,64397-12-2,79082-64-7) + (+/-)-corlumine (485-51-8,524-46-9,21414-43-7,30770-75-3,38184-69-9,64397-12-2,79082-64-7)

Guidance literature:

With chloro-trimethyl-silane; Pd(PPh₃)(OAc)2; potassium carbonate; In toluene; at 140 ℃; for 24h;

DOI:10.1021/jo982451w

Reference yield: 60.0%

carbon monoxide (201230-82-2) + 1-(2-bromo-3,4-(methylenedioxy)-α-hydroxybenzyl)-2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline → (+/-)-adlumine (485-51-8,524-46-9,21414-43-7,30770-75-3,38184-69-9,64397-12-2,79082-64-7) + (+/-)-corlumine (485-51-8,524-46-9,21414-43-7,30770-75-3,38184-69-9,64397-12-2,79082-64-7)

Guidance literature:

With chloro-trimethyl-silane; Pd(PPh₃)(OAc)2; potassium carbonate; In toluene; at 140 ℃; for 24h;

DOI:10.1021/jo982451w

upstream raw materials:

diazomethane

(R)-6-((R)-6-hydroxy-7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-yl)-6H-furo[3',4':3,4]benzo[1,2-d][1,3]dioxol-8-one

(+)-adlumine

6-((E)-6,7-dimethoxy-2-methyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-6H-furo[3',4':3,4]benzo[1,2-d][1,3]dioxol-8-one

Downstream raw materials:

(+/-)-adlumine

(+)-corlumine

(+)-corlumine

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