Technology Process of 3-[(tert-butoxycarbonyl)amino]-3-pyridin-2-ylpropanoic acid
There total 5 articles about 3-[(tert-butoxycarbonyl)amino]-3-pyridin-2-ylpropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 80 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; tert-butyl methyl ether / 1.5 h / -78 °C / Inert atmosphere
2.2: 3.5 h / -78 °C
3.1: hydrogenchloride / 1,4-dioxane / 8 h / 0 - 20 °C
4.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C
5.1: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C
With
hydrogenchloride; titanium(IV) tetraethanolate; water; sodium hydrogencarbonate; lithium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; tert-butyl methyl ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; tert-butyl methyl ether / 1.5 h / -78 °C / Inert atmosphere
1.2: 3.5 h / -78 °C
2.1: hydrogenchloride / 1,4-dioxane / 8 h / 0 - 20 °C
3.1: sodium hydrogencarbonate / 1,4-dioxane / 16 h / 20 °C
4.1: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C
With
hydrogenchloride; water; sodium hydrogencarbonate; lithium hydroxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; methanol; tert-butyl methyl ether;
