15-Hydroxy-12,13-epoxyabiet-8-ene-7,11-dione

Base Information

Chemical Name:15-Hydroxy-12,13-epoxyabiet-8-ene-7,11-dione
CAS No.:5938-11-4
Molecular Formula:C₂₀H₂₈O₄
Molecular Weight:332.44
Hs Code.:
NSC Number:114782
DSSTox Substance ID:DTXSID20974794
Nikkaji Number:J16.100D
Mol file:5938-11-4.mol

Synonyms:5938-11-4;15-hydroxy-12,13-epoxyabiet-8-ene-7,11-dione;DTXSID20974794;NSC114782;NSC-114782

Suppliers and Price of 15-Hydroxy-12,13-epoxyabiet-8-ene-7,11-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 15-Hydroxy-12,13-epoxyabiet-8-ene-7,11-dione

Chemical Property:

Vapor Pressure:1.6E-10mmHg at 25°C
Boiling Point:463.1°C at 760 mmHg
Flash Point:160.1°C
PSA：66.90000
Density:1.2g/cm³
LogP:2.96970
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:332.19875937
Heavy Atom Count:24
Complexity:686

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCCC2(C1CC(=O)C3=C2C(=O)C4C(C3)(O4)C(C)(C)O)C)C

Technology Process of 15-Hydroxy-12,13-epoxyabiet-8-ene-7,11-dione

There total 16 articles about 15-Hydroxy-12,13-epoxyabiet-8-ene-7,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 121926-98-5
12β,13β-epoxy-15-hydroxy-8-abieten-11-one

: 5938-11-4
12β,13β-epoxy-15-hydroxy-8-abieten-7,11-dione

Guidance literature:: With chromium(VI) oxide; In acetic acid; at 50 ℃;
DOI:10.1246/cl.1988.1399

Reference yield:

: 88664-08-8
(4aS,10aS)-2,3,4,4a,10,10a-hexahydro-5,6-dihydroxy-1,1,4a-trimethyl-7-(1-methylethyl)phenanthren-9(1H)-one

: 5938-11-4
12β,13β-epoxy-15-hydroxy-8-abieten-7,11-dione

Guidance literature:: Multi-step reaction with 14 steps

1: 78 percent / K₂CO₃ / 18-crown-6 / tetrahydrofuran; CH₂Cl₂

2: 97 percent / K₂CO₃ / 18-crown-6 / acetone

3: 1.) LiAlH₄; 2.) dil. HCl / 1.) THF, reflux; 2.) reflux

4: H₂ / Pd-C / acetic acid

5: 85 percent / thallium nitrate trihydrate, CaCO₃ / tetrahydrofuran

6: 41 percent / H₂ / Rh-Al₂O₃ / dioxane; aq. KOH

7: benzeneseleninic anhydride, NaH / toluene / Heating

8: 20 percent / SOCl₂ / pyridine

9: LiAlH₄ / diethyl ether

10: aq. H₂SO₄ / dioxane / 90 °C

11: 56 percent / alkaline hydrogen peroxide / methanol

12: 69 percent / Br₂, silica gel / CCl₄

13: 91 percent / Li₂CO₃, LiBr / dimethylformamide / 90 °C

14: 32 percent / CrO₃ / acetic acid / 50 °C

With chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; thallium(I) nitrate; alkaline hydrogen peroxide; sulfuric acid; benzeneseleninic anhydride; hydrogen; bromine; silica gel; lithium carbonate; sodium hydride; potassium carbonate; calcium carbonate; lithium bromide; palladium on activated charcoal; 18-crown-6 ether; rhodium on alumina; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; tetrachloromethane; potassium hydroxide; diethyl ether; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1246/cl.1988.1399

Reference yield:

: 62691-22-9
(+)-11-acetoxy-12-benzoyloxy-8,11,13-abietatrien-7-one

: 5938-11-4
12β,13β-epoxy-15-hydroxy-8-abieten-7,11-dione

Guidance literature:: Multi-step reaction with 15 steps

1: NaHCO₃ / methanol; H₂O / Heating

2: 78 percent / K₂CO₃ / 18-crown-6 / tetrahydrofuran; CH₂Cl₂

3: 97 percent / K₂CO₃ / 18-crown-6 / acetone

4: 1.) LiAlH₄; 2.) dil. HCl / 1.) THF, reflux; 2.) reflux

5: H₂ / Pd-C / acetic acid

6: 85 percent / thallium nitrate trihydrate, CaCO₃ / tetrahydrofuran

7: 41 percent / H₂ / Rh-Al₂O₃ / dioxane; aq. KOH

8: benzeneseleninic anhydride, NaH / toluene / Heating

9: 20 percent / SOCl₂ / pyridine

10: LiAlH₄ / diethyl ether

11: aq. H₂SO₄ / dioxane / 90 °C

12: 56 percent / alkaline hydrogen peroxide / methanol

13: 69 percent / Br₂, silica gel / CCl₄

14: 91 percent / Li₂CO₃, LiBr / dimethylformamide / 90 °C

15: 32 percent / CrO₃ / acetic acid / 50 °C

With chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; thallium(I) nitrate; alkaline hydrogen peroxide; sulfuric acid; benzeneseleninic anhydride; hydrogen; bromine; silica gel; lithium carbonate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; calcium carbonate; lithium bromide; palladium on activated charcoal; 18-crown-6 ether; rhodium on alumina; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; tetrachloromethane; potassium hydroxide; diethyl ether; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1246/cl.1988.1399