2,5-Dimethylquinolin-8-ol

Base Information

• Chemical Name: 2,5-Dimethylquinolin-8-ol
• CAS No.: 10522-43-7
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.214
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID10362505
• Nikkaji Number: J3.250.895B
• Wikidata: Q82145641
• ChEMBL ID: CHEMBL1460585
• Mol file: 10522-43-7.mol

Synonyms:2,5-dimethylquinolin-8-ol;10522-43-7;2,5-dimethyl-8-quinolinol;SMR000135174;MLS000530197;CHEMBRDG-BB 5175124;Cambridge id 5175124;Oprea1_720788;2,5-Dimethylquinoline-8-ol;SCHEMBL8090833;CHEMBL1460585;BDBM54191;cid_1380883;DTXSID10362505;HMS2369C06;MFCD00168975;AKOS006282523;SB67659;LS-06752;CS-0281526;EN300-180728

Chemical Property of 2,5-Dimethylquinolin-8-ol

Chemical Property:

• Vapor Pressure: 0.000157mmHg at 25°C
• Boiling Point: 321.6°C at 760 mmHg
• Flash Point: 148.3°C
• PSA: 33.12000
• Density: 1.172g/cm³
• LogP: 2.55720
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dimethyl-8-quinolinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CC(=NC2=C(C=C1)O)C

Technology Process of 2,5-Dimethylquinolin-8-ol

There total 4 articles about 2,5-Dimethylquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethanol (64-17-5) + 3-amino-4-hydroxytoluene (95-84-1) → 2,5-Dimethyl-8-hydroxy-chinolin (10522-43-7)

Guidance literature:

With 2,4,6-trimethyl-pyridine; oxygen; palladium diacetate; trifluoroacetic acid; at 150 ℃; for 36h; Schlenk technique;

DOI:10.1021/acs.joc.6b03064

Reference yield: 36.0%

butyraldehyde (123-72-8) + 3-amino-4-hydroxytoluene (95-84-1) → 2,5-Dimethyl-8-hydroxy-chinolin (10522-43-7)

Guidance literature:

With hydrogenchloride; Reflux;

DOI:10.1016/j.saa.2013.08.031

Reference yield:

trans-Crotonaldehyde (123-73-9,4170-30-3) + 3-amino-4-hydroxytoluene (95-84-1) → 2,5-Dimethyl-8-hydroxy-chinolin (10522-43-7)

Guidance literature:

With hydrogenchloride; at 90 ℃; for 5h;

DOI:10.1007/s10895-018-2275-7

upstream raw materials:

butyraldehyde

3-amino-4-hydroxytoluene

ethanol

trans-Crotonaldehyde