Dimethyl ammonium chloride

Base Information

• Chemical Name: Dimethyl ammonium chloride
• CAS No.: 506-59-2
• Molecular Formula: C2H7N^.HCl
• Molecular Weight: 81.5452
• Hs Code.: 29211190
• Mol file: 506-59-2.mol

Synonyms:dimethyl ammonium chloride

Chemical Property of Dimethyl ammonium chloride

Chemical Property:

• Appearance/Colour: white crystals
• Vapor Pressure: <0.1 hPa (25 °C)
• Melting Point: 170-173 ºC (lit.)
• Refractive Index: 1.4202 (estimate)
• Boiling Point: 6.1 ºC at 760 mmHg
• PSA: 12.03000
• Density: 0.64 g/cm³
• LogP: 1.02850
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: H2O: soluble0.5g/10 mL
• Water Solubility.: 3000 g/L (20 ºC)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 81.0345270
• Heavy Atom Count: 4
• Complexity: 2.8

Purity/Quality:

99%, ^*data from raw suppliers

Metformin impurity F European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37-37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[NH2+]C.[Cl-]
• Uses: Dimethylamine hydrochloride is a precursor to several industrially significant compounds. As accelerator in vulcanizing rubber, tanning, manufacture of detergent soaps, or attracting boll weevils to exterminate them. As reagent for Mg. Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.

Technology Process of Dimethyl ammonium chloride

There total 116 articles about Dimethyl ammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N'-dimethylbenzylamine (103-83-3) → N,N-dimethylammonium chloride (506-59-2)

Guidance literature:

With dichloromethane; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; atmospheric pressure;

DOI:10.1021/jo0480444

Reference yield: 94.1%

({(CH3)2NH}2B(Cl)C6H5)(1+)*Cl(1-)=({(CH3)2NH}2B(Cl)C6H5)Cl (94947-35-0) → chloro(dimethylamino)phenylborane (1196-44-7) + N,N-dimethylammonium chloride (506-59-2)

Guidance literature:

In neat (no solvent); pyrolysis from 150 to 200°C;;

Reference yield: 81.5%

dimethyl amine (124-40-3) + pentafluorophenyl dichlorophosphine (5032-91-7) → N,N-dimethylammonium chloride (506-59-2) + Bis-dimethylamino-pentafluorphenyl-phosphin (5032-95-1)

Guidance literature:

In diethyl ether; byproducts: HCl; in presence of a trap for HCl;

DOI:10.1021/ic50037a027

upstream raw materials:

dimethylchloroamine

Winterstein acid hydrochloride

ethyl acetate

methylene chloride

Downstream raw materials:

1H-imidazol-4-yl-N,N-dimethylmethanamine

(5-dimethylaminomethyl-furan-2-yl)-methanol

N,N-Dimethylcarbamoyl chloride

3-dimethylamino-2,2-dimethylpropanal

Refernces

• 1、 Gompper, Rudolf,Junius, Martina. "Dehydropyrroliumsalze". . p. 2883 - 2886. Retrieved 1980.
• 2、 Drane, A. Stephen,McCleverty, Jon A.. "". . p. 53 - 58. Retrieved 1983.
• 3、 Sarkar,Patra,Drew,Zangrando,Chattopadhyay. "Copper(II) complexes of tetradentate N2S2 donor sets: Synthesis, crystal structure characterization and reactivity". . p. 1 - 6. Retrieved 2009.
• 4、 Khatik, Gopal L.,Sharma, Ratnesh,Kumar, Varun,Chouhan, Mangilal,Nair, Vipin A.. "Stereoselective synthesis of (S)-dapoxetine: A chiral auxiliary mediated approach". . p. 5991 - 5993. Retrieved 2013/10/22.