6-Fluoro-naphthalene-2-carboxaldehyde

Base Information

• Chemical Name: 6-Fluoro-naphthalene-2-carboxaldehyde
• CAS No.: 721968-77-0
• Molecular Formula: C11H7FO
• Molecular Weight: 174.1710832
• Mol file: 721968-77-0.mol

Synonyms:6-Fluoro-naphthalene-2-carboxaldehyde;2-Napthalenecarboxaldehyde;6-Fluoro-2-naphthaldehyde

Chemical Property of 6-Fluoro-naphthalene-2-carboxaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 2.79140

Purity/Quality:

97% ^*data from raw suppliers

6-Fluoro-2-naphthaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoro-naphthalene-2-carboxaldehyde

There total 3 articles about 6-Fluoro-naphthalene-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-6-fluoronaphthalene (324-41-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-fluoro-2-naphthaldehyde (721968-77-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201806742

Reference yield:

(6-fluoronaphthalen-2-yl)methanol (944351-48-8) → 6-fluoro-2-naphthaldehyde (721968-77-0)

Guidance literature:

With Dess-Martin periodane; In tetrahydrofuran; chlorosulfonic acid; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201411733

Reference yield:

→ 6-fluoro-2-naphthaldehyde (721968-77-0)

Guidance literature:

upstream raw materials:

(6-fluoronaphthalen-2-yl)methanol

2-bromo-6-fluoronaphthalene

N,N-dimethyl-formamide

Downstream raw materials:

(6-fluoronaphthalen-2-yl)methanol

Refernces

• 1、 Jiménez-Moreno, Ester,G?mez, Ana M.,Bastida, Agatha,Corzana, Francisco,Jiménez-Oses, Gonzalo,Jiménez-Barbero, Jesús,Asensio, Juan Luis. "Modulating weak interactions for molecular recognition: A dynamic combinatorial analysis for assessing the contribution of electrostatics to the stability of CH-π bonds in water". supporting information. p. 4344 - 4348. Retrieved 2015/04/14.