324-41-4

Basic information

• Product Name: 2-Bromo-6-fluoronaphthalene
• Synonyms: 2-Bromo-6-fluoronaphthalene;2-fluoro-6-bromonaphthalene;5.2-Bromo-6-fluoro-naphthalene;2-Bromo-6-fluorophthalene;EOS-60456
• CAS NO: 324-41-4
• Molecular Formula: C₁₀H₆BrF
• Molecular Weight: 225.06
• EINECS: 1533716-785-6
• Product Categories: Benzene series;Fused Ring Systems;Halides;Fluorine series
• Mol File: 324-41-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 64.0 to 68.0 °C
• Boiling Point: 140°C/9mmHg(lit.)
• Flash Point: 130.8 ºC
• Appearance: /
• Density: 1.563
• Vapor Pressure: 0.00451mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-6-fluoronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-fluoronaphthalene(324-41-4)
• EPA Substance Registry System: 2-Bromo-6-fluoronaphthalene(324-41-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 324-41-4(Hazardous Substances Data)

Usage

Chemical Properties

white solid

InChI:InChI=1/C10H6BrF/c11-9-3-1-8-6-10(12)4-2-7(8)5-9/h1-6H

Upstream product

• 87700-58-1 6-fluoro-2-naphthoyl chloride 
• 5043-01-6 6-fluoro-2-naphthoic acid 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 7499-66-3 6-Bromonaphthalen-2-amine 

Downstream Products

• 3799-80-2 2-(6-Fluor-naphthoyl-⁽²⁾)-benzoesaeure 
• 38659-77-7 (C₆H₅)3SnCH₂C₁₀H₆F 
• 721968-77-0 6-fluoro-2-naphthaldehyde 
• 944351-48-8 (6-fluoronaphthalen-2-yl)methanol 
• 1426083-09-1 (2-{4-[4-(6-fluoro-naphthalen-2-yl)-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl]-phenoxy}-ethyl)-dimethyl-amine 
• 1332333-14-8 5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-[2-fluoro-4-(6-fluoro-2-naphthalenyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 5043-00-5 methyl 6-fluoro-4-methyl-2-naphthoate 
• 5043-01-6 6-fluoro-2-naphthoic acid 
• 302959-28-0 (2RS,3SR)-1,2-dimethyl-3-[2-(6-fluoronaphthyl)-3-hydroxy]pyrrolidine hydrochloride 

Relevant articles and documents

ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes

In this paper the synthesis of the racemates (2R,3S/2S,3R)-1,2-dimethyl-3-[2-(6-substituted naphthyl)]-3-hydroxypyrrolidine 1b-d [(2R,3S/2S,3R)-1b-d] are reported. Compounds 1b-d were prepared by reaction of the racemic 1,2-dimethyl-3-pyrrolidone 2 with the lithiation product obtained from 2-bromo-6-substituted naphthalene 3b-d. Pharmacological properties of (2R,3S/2S,3R)-1a-d are also described. Analgesic activity was investigated by the hot plate test and binding affinities towards μ, δ and κ opioid receptors were evaluated. A preliminary evaluation of the in vivo side-effects was also accomplished using the rota-rod test. Interesting antinociceptive activity was shown by all compounds and in particular by 1d, which is the most active compound, since it is six-fold more potent than morphine and has lower side effects on the locomotory activity. Copyright (C) 2000 Elsevier Science Ltd.