1-Piperidinecarboxylic acid, 4-(methylphenylamino)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 4-(methylphenylamino)-, 1,1-dimethylethyl ester
• CAS No.: 904679-03-4
• Molecular Formula: C₁₇H₂₆N₂O₂
• Molecular Weight: 290.406
• Mol file: 904679-03-4.mol

Synonyms:1-Piperidinecarboxylic acid, 4-(methylphenylamino)-, 1,1-dimethylethyl ester

Chemical Property of 1-Piperidinecarboxylic acid, 4-(methylphenylamino)-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 4-(methylphenylamino)-, 1,1-dimethylethyl ester

There total 2 articles about 1-Piperidinecarboxylic acid, 4-(methylphenylamino)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

1-(tert-butoxycarbonyl)-4-phenylaminopiperidine (125541-22-2) + methyl iodide (74-88-4) → 4-(methyl-phenyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (904679-03-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 7.5h;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + aniline (62-53-3) → 4-(methyl-phenyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (904679-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / 1,1-dichloroethane / 20 h / 20 °C

1.2: pH 10

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In 1,1-dichloroethane; N,N-dimethyl-formamide;

Reference yield: 100.0%

4-(methyl-phenyl-amino)-piperidine-1-carboxylic acid tert-butyl ester (904679-03-4) → 4-(N-methyl-N-phenylamino)piperidine dihydrochloride

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h;

upstream raw materials:

1-(tert-butoxycarbonyl)-4-phenylaminopiperidine

methyl iodide

N-tert-butyloxycarbonylpiperidin-4-one

aniline