5-Iodo-4-methyl-2-trifluoromethyl-pyridine

Base Information

• Chemical Name: 5-Iodo-4-methyl-2-trifluoromethyl-pyridine
• CAS No.: 944317-55-9
• Molecular Formula: C₇H₅F₃IN
• Molecular Weight: 287.023
• Hs Code.: 2933998090
• Mol file: 944317-55-9.mol

Synonyms:5-Iodo-4-methyl-2-trifluoromethyl-pyridine;2-(trifluoromethyl)-5-iodo-4-methylpyridine

Chemical Property of 5-Iodo-4-methyl-2-trifluoromethyl-pyridine

Chemical Property:

• PSA: 12.89000
• LogP: 3.01340

Purity/Quality:

98%+ ^*data from raw suppliers

5-Iodo-4-methyl-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Iodo-4-methyl-2-trifluoromethyl-pyridine

There total 3 articles about 5-Iodo-4-methyl-2-trifluoromethyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-6-(trifluoromethyl)pyridine-3-amine (944317-54-8) → 5-iodo-4-methyl-2-(trifluoromethyl)pyridine (944317-55-9)

Guidance literature:

With iodine; isopentyl nitrite; In chloroform; at 20 ℃; for 2.08333h; Heating / reflux;

Reference yield:

2-amino-5-nitro-4-picoline (21901-40-6) → 5-iodo-4-methyl-2-(trifluoromethyl)pyridine (944317-55-9)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide / N,N-dimethyl-formamide / 120 °C

2: hydrogen / platinum(IV) oxide / ethanol / 5.5 h

3: iodine; isopentyl nitrite / chloroform / 2.08 h / 20 °C / Heating / reflux

With copper(l) iodide; hydrogen; iodine; isopentyl nitrite; platinum(IV) oxide; In ethanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

4-methyl-5-nitro-2-(trifluoromethyl)pyridine (944317-53-7) → 5-iodo-4-methyl-2-(trifluoromethyl)pyridine (944317-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / platinum(IV) oxide / ethanol / 5.5 h

2: iodine; isopentyl nitrite / chloroform / 2.08 h / 20 °C / Heating / reflux

With hydrogen; iodine; isopentyl nitrite; platinum(IV) oxide; In ethanol; chloroform;

upstream raw materials:

4-methyl-6-(trifluoromethyl)pyridine-3-amine

2-amino-5-nitro-4-picoline

4-methyl-5-nitro-2-(trifluoromethyl)pyridine

Downstream raw materials:

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-iodo-2-(trifluoromethyl)pyridin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one

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