944317-53-7

Usage

Uses

Used in Pharmaceutical Industry:
PYRIDINE, 4-METHYL-5-NITRO-2-(TRIFLUOROMETHYL)is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, PYRIDINE, 4-METHYL-5-NITRO-2-(TRIFLUOROMETHYL)serves as an intermediate in the production of agrochemicals. Its incorporation into these products can contribute to the development of effective pesticides and other agricultural chemicals.
Used in Specialty Chemicals Production:
PYRIDINE, 4-METHYL-5-NITRO-2-(TRIFLUOROMETHYL)is also utilized in the manufacture of specialty chemicals. Its distinctive properties make it a valuable building block for creating customized chemical products with specific applications in various industries.
It is important to handle and store PYRIDINE, 4-METHYL-5-NITRO-2-(TRIFLUOROMETHYL)with proper care due to its potential health and environmental hazards.

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 23056-47-5 2-bromo-4-methyl-5-nitropyridine 
• 21901-40-6 2-amino-5-nitro-4-picoline 

Downstream Products

• 944317-57-1 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-iodo-2-(trifluoromethyl)pyridin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one 
• 944317-55-9 5-iodo-4-methyl-2-(trifluoromethyl)pyridine 
• 1314841-41-2 [1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[2,3-e]pyridin-2-yl]methanol 
• 1314841-39-8 ethyl 1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 
• 944317-54-8 4-methyl-6-(trifluoromethyl)pyridine-3-amine 

Relevant academic research and scientific papers

AhR MODULATORS

Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formulae: (I) wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided in the specification.

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING LACTAM COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

Novel Benzoic Pyrrolopyridine Derivatives

The present invention relates to compounds of formula: in which A, Cy, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the description. The compounds of the invention are modulators of the NURR-1 nuclear receptors.

CETP INHIBITORS

Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B is a cyclic group other than phenyl, and B has a cyclic substituent at a position that is ortho to the position at which B is connected to the remainder of the structure of Formula (I). The 5-membered ring of Formula (I) has a second cyclic substituent in addition to B.