3-AMINO-6-BROMOBIPHENYL

Base Information

• Chemical Name: 3-AMINO-6-BROMOBIPHENYL
• CAS No.: 1036750-83-0
• Molecular Formula: C12H10BrN
• Molecular Weight: 248.122
• Hs Code.: 2921499090
• Mol file: 1036750-83-0.mol

Synonyms:3-AMINO-6-BROMOBIPHENYL;4-BROMO-3-PHENYLANILINE;6-BROMOBIPHENYL-3-AMINE;6-BroMo-[1,1'-biphenyl]-3-aMine;6-Bromo-biphenyl-3-ylamine

Chemical Property of 3-AMINO-6-BROMOBIPHENYL

Chemical Property:

• PSA: 26.02000
• LogP: 4.27950
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-6-bromobiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Amino-6-bromobiphenyl is used as a reactant in the preparation of chloro aryl indolecarboxamide derivatives as inhibitors of human liver glycogen phosphorylase a. Also used in synthesis of large and stable colloidal graphene quantum dots with tunable size.

Technology Process of 3-AMINO-6-BROMOBIPHENYL

There total 5 articles about 3-AMINO-6-BROMOBIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromo-3-iodoaniline (63037-64-9) + phenylboronic acid (98-80-6) → 6-bromo-[1,1'-biphenyl]-3-amine (1036750-83-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 80 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ja1009376

Reference yield: 70.0%

2-bromo-5-nitro-1,1'-biphenyl (489409-86-1) → 6-bromo-[1,1'-biphenyl]-3-amine (1036750-83-0)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 60 ℃; for 3h;

DOI:10.1021/acs.orglett.9b02392

Reference yield:

2-amino-5-nitro-biphenyl (29608-75-1) → 6-bromo-[1,1'-biphenyl]-3-amine (1036750-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogen bromide / water; acetone / 0.17 h / 0 °C

1.2: 0.25 h / 5 °C

2.1: ammonium chloride; iron / ethanol; water / 3 h / 60 °C

With hydrogen bromide; iron; ammonium chloride; sodium nitrite; In ethanol; water; acetone;

DOI:10.1021/acs.orglett.9b02392

upstream raw materials:

2-bromo-5-nitro-1,1'-biphenyl

4-bromo-3-iodoaniline

phenylboronic acid

2-amino-5-nitro-biphenyl

Downstream raw materials:

N-(6-bromobiphenyl-3-yl)-5-chloro-1H-indole-2-carboxamide

C₅₂H₃₄N₄

C₄₈H₃₀N₂O

C₃₆H₂₄N₂