489409-86-1

Basic information

• Product Name: 2-bromo-5-nitro-1,1'-biphenyl
• Synonyms: 2-bromo-5-nitro-1,1'-biphenyl;2-Bromo-5-nitro-biphenyl;4-Hydroxymethyl-indan-1-one 1,2-ethanediol ketal
• CAS NO: 489409-86-1
• Molecular Formula: C₁₂H₈BrNO₂
• Molecular Weight: 278.10142
• Mol File: 489409-86-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-5-nitro-1,1'-biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-nitro-1,1'-biphenyl(489409-86-1)
• EPA Substance Registry System: 2-bromo-5-nitro-1,1'-biphenyl(489409-86-1)

Safety Data

• Hazardous Substances Data: 489409-86-1(Hazardous Substances Data)

Upstream product

• 63037-63-8 1-bromo-2-iodo-4-nitrobenzene 
• 98-80-6 phenylboronic acid 
• 13296-94-1 2-bromo-4-nitroaniline 
• 65975-65-7 2'-bromo-[1,1'-biphenyl]-4-amine 
• 7500-80-3 N-tosyl-5-nitro-<1,1'-biphenyl>-2-amine 
• 856352-15-3 2'-bromo-5'-nitro-biphenyl-4-ylamine 
• 10403-47-1 2-bromo 5-nitroaniline 
• 29608-75-1 2-amino-5-nitro-biphenyl 

Downstream Products

• 489409-87-2 3-(5-nitro-biphenyl-2-yl)-benzo[d]isoxazole 
• 489409-96-3 2-(benzo[d]thiazol-2-yl)-[1,1′-biphenyl]-5-amine 
• 489409-93-0 2-(5-nitro-biphenyl-2-yl)-1H-pyrrole 
• 1166975-78-5 2-(5-nitro-biphenyl-2-yl)-benzothiazole 

Relevant articles and documents

Intramolecular Remote C-H Activation via Sequential 1,4-Palladium Migration to Access Fused Polycycles

An unprecedented intramolecular remote C-H activation via sequential 1,4-palladium migration with an aromatic ring as a conveyor has been described. This reaction provides an efficient route to construct diverse polycyclic frameworks in moderate to good yield via palladium-catalyzed remote C-H activation/alkene insertion, arylation, alkenylation, and the Heck reaction. The preliminary mechanistic studies revealed that the 1,4-palladium migration process was reversible.

Through the maze: Cross-coupling pathways to a helical hexaphenyl "Gel?nder" molecule

This paper highlights a new concept on how to induce chirality in a hexaphenyl Gel?nder-type system. Bridging a terphenyl backbone with a considerably longer benzyl ether oligomer enforces a continuous twist of the molecule, while preventing an achiral me

Structurally simple inhibitors of lanosterol 14α-demethylase are efficacious in a rodent model of acute Chagas disease

We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. Several compounds display potency for killing T. cruzi amastigotes in vitro with values of EC 50 in the 0.4-10 nM range. Two compounds were selected for efficacy studies in a mouse model of acute Chagas disease. At oral doses of 20-50 mg/kg given after establishment of parasite infection, the compounds reduced parasitemia in the blood to undetectable levels, and analysis of remaining parasites by PCR revealed a lack of parasites in the majority of animals. These dialkyl imidazoles are substantially less expensive to produce than posaconazole and are appropriate for further development toward an anti-Chagas disease clinical candidate.