489409-86-1

Upstream product

• 29608-75-1 2-amino-5-nitro-biphenyl 
• 7500-80-3 N-tosyl-5-nitro-<1,1'-biphenyl>-2-amine 
• 63037-63-8 1-bromo-2-iodo-4-nitrobenzene 
• 98-80-6 phenylboronic acid 
• 13296-94-1 2-bromo-4-nitroaniline 
• 65975-65-7 2'-bromo-[1,1'-biphenyl]-4-amine 
• 856352-15-3 2'-bromo-5'-nitro-biphenyl-4-ylamine 
• 10403-47-1 2-bromo 5-nitroaniline 

Downstream Products

• 1036750-83-0 6-bromo-[1,1'-biphenyl]-3-amine 
• 489409-96-3 2-(benzo[d]thiazol-2-yl)-[1,1′-biphenyl]-5-amine 
• 489409-93-0 2-(5-nitro-biphenyl-2-yl)-1H-pyrrole 
• 1166975-78-5 2-(5-nitro-biphenyl-2-yl)-benzothiazole 
• 1166975-81-0 2-(5-nitro-biphenyl-2-yl)-benzoxazole 

Relevant academic research and scientific papers

Intramolecular Remote C-H Activation via Sequential 1,4-Palladium Migration to Access Fused Polycycles

An unprecedented intramolecular remote C-H activation via sequential 1,4-palladium migration with an aromatic ring as a conveyor has been described. This reaction provides an efficient route to construct diverse polycyclic frameworks in moderate to good yield via palladium-catalyzed remote C-H activation/alkene insertion, arylation, alkenylation, and the Heck reaction. The preliminary mechanistic studies revealed that the 1,4-palladium migration process was reversible.

COMPOUND FOR ORGANIC ELECTROLUMINESCENT DEVICE

The present invention generally discloses an organic compound and organic electroluminescence (herein referred to as organic EL) device using the organic compound. More specifically, the present invention relates to an organic EL device employing the organic compound as fluorescent emitting host or phosphorescent emitting host which can display long lifetime, high efficiency.

Through the maze: Cross-coupling pathways to a helical hexaphenyl "Gel?nder" molecule

This paper highlights a new concept on how to induce chirality in a hexaphenyl Gel?nder-type system. Bridging a terphenyl backbone with a considerably longer benzyl ether oligomer enforces a continuous twist of the molecule, while preventing an achiral me

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti-Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In addition, animal studies had demonstrated that compound 2 is highly efficacious in the acute model of the disease. However, compound 2 has a high molecular weight and high hydrophobicity, issues addressed here. Systematic modifications were carried out at four positions on the scaffold and several inhibitors were identified which are highly potent (EC50 1 nM) against T. cruzi in culture. The halogenated derivatives 36j, 36k, and 36p, display excellent activity against T. cruzi amastigotes, with reduced molecular weight and lipophilicity, and exhibit suitable physicochemical properties for an oral drug candidate.

Structurally simple inhibitors of lanosterol 14α-demethylase are efficacious in a rodent model of acute Chagas disease

We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. Several compounds display potency for killing T. cruzi amastigotes in vitro with values of EC 50 in the 0.4-10 nM range. Two compounds were selected for efficacy studies in a mouse model of acute Chagas disease. At oral doses of 20-50 mg/kg given after establishment of parasite infection, the compounds reduced parasitemia in the blood to undetectable levels, and analysis of remaining parasites by PCR revealed a lack of parasites in the majority of animals. These dialkyl imidazoles are substantially less expensive to produce than posaconazole and are appropriate for further development toward an anti-Chagas disease clinical candidate.