1-(4-Chloro-3-methoxyphenyl)ethanone

Base Information

• Chemical Name: 1-(4-Chloro-3-methoxyphenyl)ethanone
• CAS No.: 73898-63-2
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.622
• Hs Code.: 2914700090
• European Community (EC) Number: 870-868-0
• Mol file: 73898-63-2.mol

Synonyms:1-(4-Chloro-3-methoxyphenyl)ethanone;73898-63-2;1-(4-chloro-3-methoxyphenyl)ethan-1-one;Ethanone, 1-(4-chloro-3-methoxyphenyl)-;SCHEMBL8195142;AKOS006323911;DB-190468;CS-0192339;E90517;EN300-1720789;Z1198331246

Chemical Property of 1-(4-Chloro-3-methoxyphenyl)ethanone

Chemical Property:

• Boiling Point: 275.2±20.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.176±0.06 g/cm3(Predicted)
• LogP: 2.55120
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 184.0291072
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Chloro-3-methoxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC(=C(C=C1)Cl)OC

Technology Process of 1-(4-Chloro-3-methoxyphenyl)ethanone

There total 5 articles about 1-(4-Chloro-3-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(4-chloro-3-methoxyphenyl)ethan-1-ol → 1-(4-chloro-3-methoxyphenyl)ethan-1-one (73898-63-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

4-chloro-N,3-dimethoxy-N-methylbenzamide (342435-00-1) + methylmagnesium bromide (75-16-1) → 1-(4-chloro-3-methoxyphenyl)ethan-1-one (73898-63-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h;

Reference yield:

4-chloro-3-methoxybenzaldehyde (13726-16-4) → 1-(4-chloro-3-methoxyphenyl)ethan-1-one (73898-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 3.17 h / -78 - 20 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

With Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

upstream raw materials:

4-chloro-N,3-dimethoxy-N-methylbenzamide

methylmagnesium bromide

4-chloro-3-methoxybenzoic acid

4-chloro-3-methoxybenzaldehyde

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