Methyl trans-3-aMinobicyclo[2.2.2]octane-2-carboxylate hydrochloride

Base Information

• Chemical Name: Methyl trans-3-aMinobicyclo[2.2.2]octane-2-carboxylate hydrochloride
• CAS No.: 1630906-99-8
• Molecular Formula: C10H18ClNO2
• Molecular Weight: 219.70842
• Mol file: 1630906-99-8.mol

Synonyms:Methyl trans-3-aMinobicyclo[2.2.2]octane-2-carboxylate hydrochloride;(2R,3R)-rel-Methyl 3-aminobicyclo[2.2.2]octane-2-carboxylate hydrochloride

Chemical Property of Methyl trans-3-aMinobicyclo[2.2.2]octane-2-carboxylate hydrochloride

Chemical Property:

• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyltrans-3-Aminobicyclo[2.2.2]octane-2-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Methyl trans-3-Aminobicyclo[2.2.2]octane-2-carboxylate Hydrochloride is used as a reactant in the preparation of N-(substituted pyridin-2-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acids as inhibitors of influenza virus replication.

Technology Process of Methyl trans-3-aMinobicyclo[2.2.2]octane-2-carboxylate hydrochloride

There total 9 articles about Methyl trans-3-aMinobicyclo[2.2.2]octane-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester (1071521-98-6) → (2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride (1071522-01-4,1630906-99-8)

Guidance literature:

(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester; With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 25 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

Reference yield: 75.0%

cis-3-benzyloxycarbonylaminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester → cis-3-aminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride (1630906-99-8)

Guidance literature:

cis-3-benzyloxycarbonylaminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester; With hydrogen; 5%-palladium/activated carbon; In ethyl acetate; at 25 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

Reference yield:

1-hydroxybenzotriazol-hydrate (80029-43-2,123333-53-9) → methyl 3-endo-aminobicyclo[2.2.2]octane-2-exo-carboxylate hydrochloride (1630906-99-8)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane;

upstream raw materials:

1-hydroxybenzotriazol-hydrate

bicyclo[2.2.2]octane-2-endo,3-endo-dicarboxylic acid anhydride

bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic anhydride

(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

Downstream raw materials:

N-{3-[(2S,7R)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.2.02,7]dodec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

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