(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester
CAS No.:1071521-98-6
Molecular Formula:C₁₈H₂₃NO₄
Molecular Weight:317.385
Hs Code.:

Synonyms:(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

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Chemical Property of (2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

There total 4 articles about (2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1071781-53-7
(2S,3R)-bicyclo[2.2.2]octane-2,3-dicarboxylic acid monomethyl ester

: 100-51-6,185532-71-2
benzyl alcohol

: 1071521-98-6
(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

Guidance literature:: (2S,3R)-bicyclo[2.2.2]octane-2,3-dicarboxylic acid monomethyl ester; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With sodium azide; In tetrahydrofuran; water; at 0 - 25 ℃;

benzyl alcohol;

Reference yield:

: (2S,3R)-bicyclo[2.2.2]octane-2,3-dicarboxylic acid monomethyl ester

: 541-41-3
chloroformic acid ethyl ester

: 1071521-98-6
(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

Guidance literature:: With sodium azide; triethylamine; benzyl alcohol; In tetrahydrofuran; dichloromethane; water; ethyl acetate; benzene;

Reference yield:

: 6708-37-8,85081-13-6,85081-14-7
bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic anhydride

: 1071521-98-6
(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: palladium / ethyl acetate

2: Quinine / ethyl acetate; toluene; tetrachloromethane; methanol

3: triethylamine; sodium azide; benzyl alcohol / dichloromethane; ethyl acetate; benzene; water; tetrahydrofuran

With sodium azide; triethylamine; benzyl alcohol; Quinine; palladium; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; toluene; benzene;