BenzenaMine, 2,5-difluoro-4-[[2-(1-Methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-

Base Information

Chemical Name:BenzenaMine, 2,5-difluoro-4-[[2-(1-Methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-
CAS No.:1225278-35-2
Molecular Formula:C15H12F2N4O
Molecular Weight:302.283
Hs Code.:
Mol file:1225278-35-2.mol

Synonyms:BenzenaMine, 2,5-difluoro-4-[[2-(1-Methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-

Suppliers and Price of BenzenaMine, 2,5-difluoro-4-[[2-(1-Methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
2,5-Difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)aniline 95%+
100mg
$ 1540.00

Total 5 raw suppliers

Chemical Property of BenzenaMine, 2,5-difluoro-4-[[2-(1-Methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-

Chemical Property:

PSA：65.96000
LogP:3.71600

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,5-Difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)aniline 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of BenzenaMine, 2,5-difluoro-4-[[2-(1-Methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-

There total 4 articles about BenzenaMine, 2,5-difluoro-4-[[2-(1-Methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1225278-65-8
4-((2-chloropyridin-4-yl)oxy)-2,5-difluoroaniline

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1225278-35-2
2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)aniline

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

Reference yield:

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 1225278-35-2
2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.42 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 3 h / 90 °C

2.1: nickel; hydrogen / methanol / 4 h / 517.16 - 1034.32 Torr

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide; water / 90 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; nickel; sodium hydride; In methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1225278-64-7
2-chloro-4-(2 ,5-difluoro-4-nitrophenoxy)pyridine

: 1225278-35-2
2,5-difluoro-4-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: nickel; hydrogen / methanol / 4 h / 517.16 - 1034.32 Torr

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide; water / 90 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; nickel; In methanol; water; N,N-dimethyl-formamide;