2-Chloro-6-ethoxyquinoline-3-methanol

Base Information

Chemical Name:2-Chloro-6-ethoxyquinoline-3-methanol
CAS No.:333408-52-9
Molecular Formula:C12H12ClNO2
Molecular Weight:237.68
Hs Code.:2933499090
European Community (EC) Number:803-456-6
DSSTox Substance ID:DTXSID10357714
Wikidata:Q82137751
Mol file:333408-52-9.mol

Synonyms:2-Chloro-6-ethoxyquinoline-3-methanol;333408-52-9;(2-chloro-6-ethoxyquinolin-3-yl)methanol;Oprea1_146445;Oprea1_766516;DTXSID10357714;MFCD02741774;AKOS000731943;2-Chloro-6-ethoxyquinoline-3-methanol, AldrichCPR

Suppliers and Price of 2-Chloro-6-ethoxyquinoline-3-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-Chloro-6-ethoxyquinoline-3-methanol
5 g
$ 928.00

SynQuest Laboratories
2-Chloro-6-ethoxyquinoline-3-methanol
1 g
$ 328.00

Sigma-Aldrich
2-Chloro-6-ethoxyquinoline-3-methanol Aldrich
1g
$ 223.00

American Custom Chemicals Corporation
2-CHLORO-6-ETHOXYQUINOLINE-3-METHANOL 95.00%
5MG
$ 499.33

AK Scientific
2-Chloro-6-ethoxyquinoline-3-methanol
1g
$ 328.00

Total 2 raw suppliers

Chemical Property of 2-Chloro-6-ethoxyquinoline-3-methanol

Chemical Property:

Vapor Pressure:3.85E-07mmHg at 25°C
Boiling Point:400.7°C at 760 mmHg
Flash Point:196.1°C
PSA：42.35000
Density:1.298g/cm³
LogP:2.77920
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:237.0556563
Heavy Atom Count:16
Complexity:227

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-ethoxyquinoline-3-methanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 41
Safety Statements: 26-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC2=CC(=C(N=C2C=C1)Cl)CO

Technology Process of 2-Chloro-6-ethoxyquinoline-3-methanol

There total 2 articles about 2-Chloro-6-ethoxyquinoline-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 281208-98-8
2-chloro-6-ethoxyquinoline-3-carbaldehyde

: 333408-52-9
3-(hydroxymethyl)-2-chloro-6-ethoxyquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1134/S1070428009030142

Reference yield:

: 62-44-2,105931-34-8
4-ethoxyacetanilide

: 333408-52-9
3-(hydroxymethyl)-2-chloro-6-ethoxyquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 80 - 90 °C

2: methanol; sodium tetrahydroborate / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; trichlorophosphate;
DOI:10.1007/s12039-011-0127-y

Reference yield: 83.0%

: 333408-52-9
3-(hydroxymethyl)-2-chloro-6-ethoxyquinoline

: 98-59-9
p-toluenesulfonyl chloride

: 1334446-25-1
(2-chloro-6-ethoxyquinolin-3-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: 3-(hydroxymethyl)-2-chloro-6-ethoxyquinoline; With triethylamine; In dichloromethane;

p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.5012/bkcs.2011.32.7.2171