Chemical Property of Phenacetin
Chemical Property:
- Appearance/Colour:white crystalline powder
- Vapor Pressure:3.21E-05mmHg at 25°C
- Melting Point:133-136 °C(lit.)
- Refractive Index:1.548
- Boiling Point:355.1 °C at 760 mmHg
- PKA:pKa 2.2(H2O) (Uncertain);3.5(aqueous acetone) (Uncertain)
- Flash Point:168.5 °C
- PSA：38.33000
- Density:1.099 g/cm3
- LogP:2.11670
- Storage Temp.:2-8°C
- Sensitive.:Hygroscopic
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- Water Solubility.:0.076 g/100 mL
- XLogP3:1.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:3
- Exact Mass:179.094628657
- Heavy Atom Count:13
- Complexity:162
- Purity/Quality:
-
99% *data from raw suppliers
Phenacetin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:T,F
- Statements:
45-22-20/21/22-36-11
- Safety Statements:
53-45-36/37-26-16
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CCOC1=CC=C(C=C1)NC(=O)C
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Uses
Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics (Flower et al. 1985) and was withdrawn from the U.S. market in 1983 (Ronco and Flahault 1994, FDA 1998, 1999). Phenacetin also was previously used as a stabilizer for hydrogen peroxide in hair-bleaching preparations (IARC 1980, HSDB 2009). Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine.
Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens. glycosylation inhibitor Phenacetin was used as an analgesic and fever-reducing drug in
both human and veterinary medicine for many years until it
was implicated in kidney disease (nephropathy) due to abuse
of analgesics and was withdrawn from the market. Phenacetin
also was previously used as a stabilizer for hydrogen peroxide
in hair-bleaching preparations.
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Description
Phenacetin, a painkiller, was the world’s first synthetic pharmaceutical
drug. It was one of the first painkillers that was not
derived from opium while at the same time being absent of antiinflammatory
qualities. Phenacetinwas developed in 1878 by an
American chemist, Harmon Northrop Morse. It was introduced
into the pharmaceutical market in 1887. However, it was withdrawn
in 1983 in the United States due to unacceptable levels of
interstitial nephritis in patients and potential risks of tumorigenicity.
Like in the United States, most Western countries did not
ban phenacetin from marketing until 1983. Phenacetin is
a component of APC (aspirin-phenacetin-caffeine).
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Therapeutic Function
Analgesic
