TERT-BUTYL 4-CHLORO-2-(CHLOROMETHYL)BENZYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-CHLORO-2-(CHLOROMETHYL)BENZYLCARBAMATE
• CAS No.: 928754-18-1
• Molecular Formula: C₁₃H₁₇Cl₂NO₂
• Molecular Weight: 290.189
• Mol file: 928754-18-1.mol

Synonyms:TERT-BUTYL 4-CHLORO-2-(CHLOROMETHYL)BENZYLCARBAMATE

Chemical Property of TERT-BUTYL 4-CHLORO-2-(CHLOROMETHYL)BENZYLCARBAMATE

Chemical Property:

• PSA: 41.82000
• LogP: 4.30790

Purity/Quality:

TERT-BUTYL-4-CHLORO-2-(CHLOROMETHYL)BENZYLCARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-CHLORO-2-(CHLOROMETHYL)BENZYLCARBAMATE

There total 6 articles about TERT-BUTYL 4-CHLORO-2-(CHLOROMETHYL)BENZYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + tert-butyl 4-chloro-2-(hydroxymethyl)benzylcarbamate (439117-40-5) → (4-chloro-2-chloromethyl-benzyl)-carbamic acid tert-butyl ester (928754-18-1) + methanesulfonic acid 2-(tert-butoxycarbonylamino-methyl)-5-chloro-benzyl ester

Guidance literature:

With triethylamine; In Isopropyl acetate; at -15 - 20 ℃;

DOI:10.1021/jo035794p

Reference yield:

methyl-2-bromo-5-chlorobenzoate (27007-53-0) → (4-chloro-2-chloromethyl-benzyl)-carbamic acid tert-butyl ester (928754-18-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / dimethylformamide / 4 h / 90 °C

2: BH₃*DMS

3: 93 percent / toluene / 6 h / 20 °C

4: Et₃N / isopropyl acetate / -15 - 20 °C

With dimethylsulfide borane complex; triethylamine; In Isopropyl acetate; N,N-dimethyl-formamide; toluene; 1: Rosenmund-von Braun reaction;

DOI:10.1021/jo035794p

Reference yield:

methyl 5-chloro-2-cyanobenzoate (439117-38-1) → (4-chloro-2-chloromethyl-benzyl)-carbamic acid tert-butyl ester (928754-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: BH₃*DMS

2: 93 percent / toluene / 6 h / 20 °C

3: Et₃N / isopropyl acetate / -15 - 20 °C

With dimethylsulfide borane complex; triethylamine; In Isopropyl acetate; toluene;

DOI:10.1021/jo035794p

upstream raw materials:

methanesulfonyl chloride

tert-butyl 4-chloro-2-(hydroxymethyl)benzylcarbamate

di-tert-butyl dicarbonate

methyl-2-bromo-5-chlorobenzoate

Refernces