2,6,7-Trichloroquinoxaline

Base Information

• Chemical Name: 2,6,7-Trichloroquinoxaline
• CAS No.: 41213-31-4
• Molecular Formula: C8H3Cl3N2
• Molecular Weight: 233.48
• Hs Code.: 2933990090
• European Community (EC) Number: 807-177-0
• DSSTox Substance ID: DTXSID90434557
• Wikidata: Q82249012
• Mol file: 41213-31-4.mol

Synonyms:2,6,7-trichloroquinoxaline;41213-31-4;2,6,7-Trichloro-quinoxaline;SCHEMBL2552603;DTXSID90434557;WKHZLRADDUHIIV-UHFFFAOYSA-N;MFCD11519427;AKOS016013308;SB74939;AM807607;AS-32296;CS-0452246;FT-0739018;EN300-131355;A849234;Z1269188384

Chemical Property of 2,6,7-Trichloroquinoxaline

Chemical Property:

• PSA: 25.78000
• LogP: 3.59000
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 231.936181
• Heavy Atom Count: 13
• Complexity: 190

Purity/Quality:

99% ^*data from raw suppliers

2,6,7-Trichloroquinoxaline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C2C(=CC(=C1Cl)Cl)N=C(C=N2)Cl

Technology Process of 2,6,7-Trichloroquinoxaline

There total 7 articles about 2,6,7-Trichloroquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6,7-dichloroquinoxaline-2(1H)-one (78470-95-8) → 2,6,7-trichloro-quinoxaline (41213-31-4)

Guidance literature:

With trichlorophosphate; for 3h; Heating;

DOI:10.1021/jm00096a002

Reference yield:

6,7-dichloro-2-hydroxyquinoxaline → 2,6,7-trichloro-quinoxaline (41213-31-4)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

Reference yield:

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) → 2,6,7-trichloro-quinoxaline (41213-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / ethanol / 3 h / Heating

2: 92 percent / phosphorus oxychloride / 3 h / Heating

With trichlorophosphate; In ethanol;

DOI:10.1021/jm00096a002

upstream raw materials:

6,7-dichloroquinoxaline-2(1H)-one

4,5-Dichloro-1,2-phenylenediamine

6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acid

1,2-dichloro-4,5-dinitrobenzene

Downstream raw materials:

1-Phenyl-7,8-dichloro-1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-one

1-Phenyl-7,8-dichloro-1,2,4-triazolo [4,3-a]quinoxaline

4-(6,7-Dichloro-quinoxalin-2-yloxy)-phenol

Ethyl 4-[4-(6,7-dichloro-2-quinoxalyloxy)phenoxy]-3-oxopentanoate

Refernces

• 1、 Thompson, Andrew J.,Verheij, Mark H. P.,VanMuijlwijk-Koezen, Jacqueline E.,Lummis, Sarah C. R.,Leurs, Rob,DeEsch, Iwan J. P.. "Structure-Activity Relationships of Quinoxaline-Based 5-HT3A and 5-HT3AB Receptor-Selective Ligands". . p. 946 - 955. Retrieved 2013/07/27.
• 2、 -. "NON-PEPTIDE GLP-1 AGONISTS". Page/Page column 56. . Retrieved 2010/02/13.