3-ethynyl-3-Methyloxetane

Base Information

• Chemical Name: 3-ethynyl-3-Methyloxetane
• CAS No.: 1290541-27-3
• Molecular Formula: C6H8O
• Molecular Weight: 96.1289
• Mol file: 1290541-27-3.mol

Synonyms:3-ethynyl-3-Methyloxetane

Chemical Property of 3-ethynyl-3-Methyloxetane

Chemical Property:

• PSA: 9.23000
• LogP: 0.65610

Purity/Quality:

97% ^*data from raw suppliers

3-Ethynyl-3-methyloxetane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-ethynyl-3-Methyloxetane

There total 4 articles about 3-ethynyl-3-Methyloxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyloxetane-3-carboxaldehyde (99419-31-5) + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → 3-ethynyl-3-methyloxetane (1290541-27-3)

Guidance literature:

With potassium carbonate; In methanol; at 0 - 20 ℃; for 2h;

Reference yield:

3-hydroxymethyl-3-methyloxethane (3143-02-0) → 3-ethynyl-3-methyloxetane (1290541-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate; silica gel / dichloromethane / 24 h / Inert atmosphere

2.1: triphenylphosphine / dichloromethane / 0.5 h / Inert atmosphere

2.2: 1 h / 23 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Inert atmosphere; Cooling with acetone-dry ice

With n-butyllithium; silica gel; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm5012676

Reference yield:

3-methyloxetane-3-carboxaldehyde (99419-31-5) → 3-ethynyl-3-methyloxetane (1290541-27-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine / dichloromethane / 0.5 h / Inert atmosphere

1.2: 1 h / 23 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / Inert atmosphere; Cooling with acetone-dry ice

With n-butyllithium; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm5012676

upstream raw materials:

3-hydroxymethyl-3-methyloxethane

3-methyloxetane-3-carboxaldehyde

3-(2,2-dibromoethenyl)-3-methyloxetane

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

Downstream raw materials:

(S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine

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