3-Methyl-3-oxetanemethanol

Base Information

• Chemical Name: 3-Methyl-3-oxetanemethanol
• CAS No.: 3143-02-0
• Molecular Formula: C5H10O2
• Molecular Weight: 102.133
• Hs Code.: 29329990
• Mol file: 3143-02-0.mol

Synonyms:(3-Methyloxetan-3-yl)methanol;3-(Hydroxymethyl)-3-methyloxetane;3-Methyl-3-(hydroxymethyl)oxacyclobutane;3-Methyl-3-(hydroxymethyl)oxetane;3-Methyl-3-oxetanylmethyl alcohol;MOXA(monomer);3-Hydroxymethyl-3-methyloxetane;

Chemical Property of 3-Methyl-3-oxetanemethanol

Chemical Property:

• Appearance/Colour: clear colorless to pale yellow liquid
• Vapor Pressure: 1.32mmHg at 25°C
• Refractive Index: n20/D 1.446(lit.)
• Boiling Point: 152.2 °C at 760 mmHg
• PKA: 14.58±0.10(Predicted)
• Flash Point: 98.9 °C
• PSA: 29.46000
• Density: 1.031 g/cm³
• LogP: 0.01520
• Storage Temp.: 2-8°C
• Solubility.: Soluble in chloroform, methanol.

Purity/Quality:

98%, ^*data from raw suppliers

3-(Hydroxymethyl)-3-methyloxetane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 23-24/25-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Methyl-3-oxetanemethanol has been used in the preparation of star-shaped copolymer consisting of a hyperbranched poly(3-methyl-3-oxetanemethanol) core and polytetrahydrofuran arms, pyridyl disulfide-functionalized cyclic carbonate monomer, required for the synthesis of of functional poly(ε-caprolactone) containing pendant pyridyl disulphide groups and δ-lactams. It is used to synthesize octahydroindole alkaloids and γ-butenolides.

Technology Process of 3-Methyl-3-oxetanemethanol

There total 14 articles about 3-Methyl-3-oxetanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyl[(3-methyloxetan-3-yl)methoxy]diphenylsilane (1620017-21-1) → 3-hydroxymethyl-3-methyloxethane (3143-02-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2014.06.024

Reference yield: 83.7%

2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) → 3-hydroxymethyl-3-methyloxethane (3143-02-0)

Guidance literature:

With potassium hydroxide; Diethyl carbonate; at 115 ℃; for 1h;

Reference yield: 24.0%

1,1,1-Trimethylolethane dinitrate (84051-79-6) → 3-hydroxymethyl-3-methyloxethane (3143-02-0) + 2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) + ethyl nitrate (625-58-1) + 1,1,1-Trimethylolethane mononitrate (84051-80-9) + 3-methyl-3-(nitroxymethyl)oxetane (84051-81-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 55 ℃; for 3.10833h; Product distribution; Rate constant; var. NaOH conc.;

DOI:10.1021/jo00151a008

upstream raw materials:

2-(hydroxymethyl)-2-methylpropane-1,3-diol

trimethylolethane trinitrate

2-(bromomethyl)-2-methylpropane-1,3-diol

Diethyl carbonate

Downstream raw materials:

2-(bromomethyl)-2-methylpropane-1,3-diol

2-methoxymethyl-2-methyl-1,3-propanediol

2-methyl-2-(phenylselenyl)methylpropane-1,3-diol

(1R^*,2S^*,5S^*)-(3-methyl-3-oxetanyl)methyl 2-acetoxy-5-methyl-3-cyclohexenecarboxylate