Sulfamethazine-D4

Base Information

• Chemical Name: Sulfamethazine-D4
• CAS No.: 1020719-82-7
• Molecular Formula: C₁₂H₁₄N₄O₂S
• Molecular Weight: 282.303
• Mol file: 1020719-82-7.mol

Synonyms:Sulfamethazine-D4;Sulfadimidine-d4 (discontinued see S699072 the same compound);4-AMino-N-(4,6-diMethyl-2-pyriMidinyl)benzene-2,3,5,6-d4-sulfonaMide;4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene-2,3,5,6-d4-sulfonamide

Chemical Property of Sulfamethazine-D4

Chemical Property:

• Melting Point: 200-201°C
• PSA: 106.35000
• LogP: 3.21140
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol

Purity/Quality:

NLT 98% ^*data from raw suppliers

Sulfamethazine-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antibacterial. The isotopically labelled antibacterial drug Sulfadimidin.

Technology Process of Sulfamethazine-D4

There total 7 articles about Sulfamethazine-D4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

C14H12(2)H4N4O3S → sulfamethazine-d4 (1020719-82-7)

Guidance literature:

With sodium hydroxide; for 0.5h; Heating;

Reference yield:

sulfadimesine (57-68-1) → [G-2H]sulfamethazine (1020719-82-7)

Guidance literature:

With hydrogen; water-d2; palladium on activated charcoal; for 24h; under 760 Torr; Heating;

DOI:10.1016/j.tet.2006.08.088

Reference yield:

aniline-d5 (4165-61-1) → sulfamethazine-d4 (1020719-82-7)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium acetate; acetic acid / 0.5 h / 30 °C

2: chlorosulfonic acid / 0.33 h / 60 °C

3: pyridine / 1 h / 30 - 55 °C

4: sodium hydroxide / 0.5 h / Heating

With chlorosulfonic acid; sodium acetate; acetic acid; sodium hydroxide; In pyridine;

upstream raw materials:

sulfadimesine

aniline-d5

acetanilide-d5

p-acetamidobenzenesulfonyl chloride-d₄

Refernces

• 1、 Esaki, Hiroyoshi,Ito, Nobuhiro,Sakai, Shino,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao. "General method of obtaining deuterium-labeled heterocyclic compounds using neutral D2O with heterogeneous Pd/C". . p. 10954 - 10961. Retrieved 2007/10/03.