4-HYDROXY-3-IODOBENZYL ALCOHOL

Base Information

• Chemical Name: 4-HYDROXY-3-IODOBENZYL ALCOHOL
• CAS No.: 197230-74-3
• Molecular Formula: C7H7IO2
• Molecular Weight: 250.036
• Mol file: 197230-74-3.mol

Synonyms:4-HYDROXY-3-IODOBENZYL ALCOHOL;4-(hydroxymethyl)-2-iodophenol;BENZENEMETHANOL,4-HYDROXY-3-IODO-;T3 intermediates

Chemical Property of 4-HYDROXY-3-IODOBENZYL ALCOHOL

Chemical Property:

• PSA: 40.46000
• LogP: 1.48910
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

≥99.0% ^*data from raw suppliers

4-(Hydroxymethyl)-2-iodophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Hydroxymethyl)-2-iodophenol is a reagent that is used in the synthesis of 3,3’,5-Triiodo-D-thyronine (T795375), which has been shown to reduce cholesterol in blood serum.

Technology Process of 4-HYDROXY-3-IODOBENZYL ALCOHOL

There total 2 articles about 4-HYDROXY-3-IODOBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 3-iodo-4-hydroxybenzoate (15126-06-4) → 4-(hydroxymethyl)-2-iodophenol (197230-74-3)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 - 20 ℃; for 2.5h; Inert atmosphere; Schlenk technique;

Reference yield: 92.0%

(4-hydroxyphenyl)methanol (623-05-2) → 4-(hydroxymethyl)-2-iodophenol (197230-74-3)

Guidance literature:

With ammonium peroxydisulfate; potassium iodide; In methanol; water; at 20 ℃;

DOI:10.1055/s-0029-1218698

Reference yield: 79.0%

4-(hydroxymethyl)-2-iodophenol (197230-74-3) + phenylacetylene (536-74-3) → 2-phenyl-5-hydroxymethylbenzofuran

Guidance literature:

With Pd-Cu/C; ethanolamine; triphenylphosphine; In water; at 80 ℃; for 20h; Sealed tube; Inert atmosphere;

DOI:10.3762/bjoc.9.160

upstream raw materials:

(4-hydroxyphenyl)methanol

methyl 3-iodo-4-hydroxybenzoate

Refernces

• 1、 -. "COMPOUNDS USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES". Page/Page column 37. . Retrieved 2015/04/15.