(2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:(2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:1378391-86-6
Molecular Formula:C14H22IN3O3
Molecular Weight:407.251
Hs Code.:
Mol file:1378391-86-6.mol

Synonyms:(2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Suppliers and Price of (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property:

Boiling Point:509.7±40.0 °C(Predicted)
PKA:11.70±0.10(Predicted)
PSA：67.45000
Density:1.515±0.06 g/cm3(Predicted)
LogP:2.89670

Purity/Quality:: 99% Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

There total 10 articles about (2S,4S)-2-(5-Iodo-1H-imidazol-2-yl)-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4S)-N-(tert-butyloxycarbonyl)-2-(4,5-diiodo-1H-imidazol-2-yl)-4-(methoxymethyl)-pyrrolidine

: 1378391-86-6
(2S,4S)-tert-butyl 2-(5-iodo-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: With sodium thiosulfate; In ethanol; water; at 90 - 100 ℃; for 22h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1378391-86-6
(2S,4S)-tert-butyl 2-(5-iodo-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 16 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 5 h / 0 °C

3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.75 h / 0 °C

3.2: 2 h / 0 °C

4.1: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

6.1: borane dimethyl sulfide complex / tetrahydrofuran / 22 h / 0 - 20 °C

7.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium bromide; sodium hydrogencarbonate; sodium hypochlorite / dichloromethane; water / 2 h / 20 °C

8.1: ammonium hydroxide / water; methanol / 20 °C

9.1: iodine; sodium carbonate / 1,4-dioxane / Darkness

10.1: sodium thiosulfate / ethanol; water / 22 h / 90 - 100 °C

With dmap; sodium hypochlorite; 2,6-di-tert-butyl-pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; borane dimethyl sulfide complex; water; iodine; silver trifluoromethanesulfonate; chloroformic acid ethyl ester; sodium hydrogencarbonate; sodium carbonate; ammonium hydroxide; sodium thiosulfate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium bromide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;

Reference yield:

: 1378388-30-7
(2S,4S)-N-(tert-butyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid dimethyl ester

: 1378391-86-6
(2S,4S)-tert-butyl 2-(5-iodo-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / tetrahydrofuran / 5 h / 0 °C

2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.75 h / 0 °C

2.2: 2 h / 0 °C

3.1: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

5.1: borane dimethyl sulfide complex / tetrahydrofuran / 22 h / 0 - 20 °C

6.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium bromide; sodium hydrogencarbonate; sodium hypochlorite / dichloromethane; water / 2 h / 20 °C

7.1: ammonium hydroxide / water; methanol / 20 °C

8.1: iodine; sodium carbonate / 1,4-dioxane / Darkness

9.1: sodium thiosulfate / ethanol; water / 22 h / 90 - 100 °C

With sodium hypochlorite; 2,6-di-tert-butyl-pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; borane dimethyl sulfide complex; water; iodine; silver trifluoromethanesulfonate; chloroformic acid ethyl ester; sodium hydrogencarbonate; sodium carbonate; ammonium hydroxide; sodium thiosulfate; triethylamine; sodium bromide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;