(2S,4S)-1-tert-butyl 2,4-dimethyl pyrrolidine-1,2,4-tricarboxylate

Base Information

Chemical Name:(2S,4S)-1-tert-butyl 2,4-dimethyl pyrrolidine-1,2,4-tricarboxylate
CAS No.:1378388-30-7
Molecular Formula:C₁₃H₂₁NO₆
Molecular Weight:287.313
Hs Code.:
European Community (EC) Number:807-497-0
DSSTox Substance ID:DTXSID201125766
Nikkaji Number:J2.751.079E
Mol file:1378388-30-7.mol

Synonyms:SCHEMBL6122335;OGALWEUKFZWWKV-IUCAKERBSA-N;DTXSID201125766;(2S,4S)-1-tert-butyl 2,4-dimethyl pyrrolidine-1,2,4-tricarboxylate;1-(tert-Butoxycarbonyl)-4alpha-(methoxycarbonyl)-L-proline methyl ester;1,2,4-Pyrrolidinetricarboxylic acid, 1-(1,1-dimethylethyl) 2,4-dimethyl ester, (2S,4S)-;1378388-30-7

Suppliers and Price of (2S,4S)-1-tert-butyl 2,4-dimethyl pyrrolidine-1,2,4-tricarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (2S,4S)-1-tert-butyl 2,4-dimethyl pyrrolidine-1,2,4-tricarboxylate

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:287.13688739
Heavy Atom Count:20
Complexity:400

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)OC)C(=O)OC
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@H](C[C@H]1C(=O)OC)C(=O)OC

Technology Process of (2S,4S)-1-tert-butyl 2,4-dimethyl pyrrolidine-1,2,4-tricarboxylate

There total 1 articles about (2S,4S)-1-tert-butyl 2,4-dimethyl pyrrolidine-1,2,4-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1378388-30-7
(2S,4S)-N-(tert-butyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 16.5 h / 0 - 25 °C

2: triethylamine / dichloromethane / 16 h / 0 - 25 °C

3: dimethyl sulfoxide / 16 h / 80 °C

4: water; sodium hydroxide / tetrahydrofuran / 16 h

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C

With water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield: 70.0%

: 1378388-30-7
(2S,4S)-N-(tert-butyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid dimethyl ester

: 1378388-35-2
(3S,5S)-N-(tert-butoxycarbonyl)-5-(methoxycarbonyl)-pyrrolidine-3-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tert-Amyl alcohol; at 0 ℃; for 5.25h; Cooling with ice;

Reference yield:

: 1378388-30-7
(2S,4S)-N-(tert-butyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid dimethyl ester

: 1377049-84-7
methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 12 steps

1: water; sodium hydroxide / tert-Amyl alcohol / 5.25 h / 0 °C / Cooling with ice

2: triethylamine / tetrahydrofuran / 0.75 h / 0 °C / Cooling with ice

3: water; sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Cooling with ice

4: silver trifluoromethanesulfonate; 2,6-di-tert-butyl-pyridine / dichloromethane / 3 h / 0 - 20 °C / Cooling with ice

5: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

6: caesium carbonate / 4 h / 20 °C

7: pyridinium hydrobromide perbromide / dichloromethane; methanol / 1.75 h / 20 °C

8: caesium carbonate / 20 h / 50 °C

9: ammonium acetate / toluene; 2-methoxy-ethanol / 4.5 h / 110 °C

10: manganese(IV) oxide / dichloromethane / 13 h

11: hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

12: N-ethyl-N,N-diisopropylamine; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; 2,6-di-tert-butyl-pyridine; pyridinium hydrobromide perbromide; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; ammonium acetate; water; silver trifluoromethanesulfonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide; toluene;