(S)-benzyl 3-(hydroxymethyl)piperazine-1-carboxylate

Base Information

• Chemical Name: (S)-benzyl 3-(hydroxymethyl)piperazine-1-carboxylate
• CAS No.: 930837-02-8
• Molecular Formula: C13H18N2O3
• Molecular Weight: 250.298
• Mol file: 930837-02-8.mol

Synonyms:(S)-benzyl 3-(hydroxymethyl)piperazine-1-carboxylate;(3S)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid phenylmethyl ester

Chemical Property of (S)-benzyl 3-(hydroxymethyl)piperazine-1-carboxylate

Chemical Property:

• PSA: 61.80000
• LogP: 0.85600

Purity/Quality:

99% ^*data from raw suppliers

(S)-Benzyl3-(hydroxymethyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-benzyl 3-(hydroxymethyl)piperazine-1-carboxylate

There total 1 articles about (S)-benzyl 3-(hydroxymethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + (S)-2-hydroxymethylpiperazine (126872-94-4) → benzyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (930837-02-8,930837-03-9)

Guidance literature:

In ISOPROPYLAMIDE; water; acetonitrile; at 0 - 20 ℃; for 0.25h;

Reference yield: 90.0%

benzyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (930837-02-8,930837-03-9) + di-tert-butyl dicarbonate (24424-99-5) → (S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (385802-84-6,557056-07-2)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 30 ℃; for 4h;

Reference yield: 25.78%

benzyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (930837-02-8,930837-03-9) + tert-butyldimethylsilyl chloride (18162-48-6) → benzyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxymethyl]piperazine-1-carboxylate

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 25 ℃; for 2h;

upstream raw materials:

N-(Benzyloxycarbonyloxy)succinimide

(S)-2-hydroxymethylpiperazine

Downstream raw materials:

(S)-4-benzyl 1-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate