3-Hydroxy-5-nitro-1H-pyrazolo[3,4-b]pyridine

Base Information

Chemical Name:3-Hydroxy-5-nitro-1H-pyrazolo[3,4-b]pyridine
CAS No.:1186609-73-3
Molecular Formula:C6H4N4O3
Molecular Weight:180.12
Hs Code.:
Mol file:1186609-73-3.mol

Synonyms:3-Hydroxy-5-nitro-1H-pyrazolo[3,4-b]pyridine

Suppliers and Price of 3-Hydroxy-5-nitro-1H-pyrazolo[3,4-b]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Nitro-1H,2H,3H-pyrazolo[3,4-b]pyridin-3-one
25mg
$ 65.00

AccelPharmtech
1,2-dihydro-5-nitro-3H-Pyrazolo[3,4-b]pyridin-3-one 97.00%
25G
$ 6000.00

AccelPharmtech
1,2-dihydro-5-nitro-3H-Pyrazolo[3,4-b]pyridin-3-one 97.00%
5G
$ 3230.00

AccelPharmtech
1,2-dihydro-5-nitro-3H-Pyrazolo[3,4-b]pyridin-3-one 97.00%
1G
$ 1890.00

Total 3 raw suppliers

Chemical Property of 3-Hydroxy-5-nitro-1H-pyrazolo[3,4-b]pyridine

Chemical Property:

PSA：107.62000
LogP:1.09490

Purity/Quality:

98% ^*data from raw suppliers

5-Nitro-1H,2H,3H-pyrazolo[3,4-b]pyridin-3-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Hydroxy-5-nitro-1H-pyrazolo[3,4-b]pyridine

There total 1 articles about 3-Hydroxy-5-nitro-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34461-00-2
nitromalondialdehyde sodium salt

: 53666-79-8
5-amino-2H-pyrazol-3-ol

: 1186609-73-3
5-nitro-1H-pyrazolo[3,4-b]pyridin-3-ol

Guidance literature:: With acetic acid; at 90 ℃; for 6h; Sealed tube;

Reference yield:

: 1186609-73-3
5-nitro-1H-pyrazolo[3,4-b]pyridin-3-ol

: 1186607-63-5
6-chloro-N-(3-ethoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-fluoro-3-(propylsulfonamido)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / 72 h / 20 °C / Inert atmosphere of nitrogen

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere of N₂

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.42 h / 20 °C

4.2: 4 h

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With dmap; di-isopropyl azodicarboxylate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1186609-73-3
5-nitro-1H-pyrazolo[3,4-b]pyridin-3-ol

: 1186609-40-4
tert-butyl 5-(6-chloro-2-fluoro-3-(propylsulfonamido)benzamido)-3-ethoxy-1H-pyrazolo[3,4-b]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / 72 h / 20 °C / Inert atmosphere of nitrogen

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere of N₂

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 2 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.42 h / 20 °C

4.2: 4 h

With dmap; di-isopropyl azodicarboxylate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;