2-Methyl-[1,1'-biphenyl]-3-ol

Base Information

• Chemical Name: 2-Methyl-[1,1'-biphenyl]-3-ol
• CAS No.: 106912-94-1
• Molecular Formula: C13H12O
• Molecular Weight: 184.238
• Hs Code.: 2907199090
• UNII: P4K8NCV7K6
• Nikkaji Number: J161.447I
• Mol file: 106912-94-1.mol

Synonyms:2-Methyl-[1,1'-biphenyl]-3-ol;106912-94-1;2-methyl-3-phenylphenol;2/'-METHYL[1,1/'-BIPHENYL]-3-OL;MFCD24715211;2-Methylbiphenyl-3-ol;a-Phenyl-o-kresol;P4K8NCV7K6;SCHEMBL2860776;RDCHMDPGLCHQQM-UHFFFAOYSA-N;2-Methyl[1,1'-biphenyl]-3-ol;AC2839;AKOS022187543;[1,1'-Biphenyl]-3-ol, 2-methyl-;DS-8777;SY096689;CS-0045388;A925033

Chemical Property of 2-Methyl-[1,1'-biphenyl]-3-ol

Chemical Property:

• PSA: 20.23000
• LogP: 3.36760
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 184.088815002
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-[1,1'-biphenyl]-3-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC=C1O)C2=CC=CC=C2

Technology Process of 2-Methyl-[1,1'-biphenyl]-3-ol

There total 21 articles about 2-Methyl-[1,1'-biphenyl]-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-bromo-2-methylphenol (7766-23-6) + phenylboronic acid (98-80-6) → 2-methyl-[1,1’-biphenyl]-3-ol (106912-94-1)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; toluene; at 80 ℃; Inert atmosphere;

Reference yield: 95.0%

3-(benzyloxy)-2-methyl-1,1’-biphenyl → 2-methyl-[1,1’-biphenyl]-3-ol (106912-94-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; water; at 20 ℃; for 72h;

Reference yield: 75.0%

2-methyl-3-phenyl-4-chloro-3-cyclobutenone (16547-35-6) + tri-n-butyl(vinyl)tin (7486-35-3) → 2-methyl-[1,1’-biphenyl]-3-ol (106912-94-1)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; trifuran-2-yl-phosphane; In 1,4-dioxane; at 100 ℃; for 6h;

DOI:10.1021/ja00030a043

upstream raw materials:

4-methyl-4-phenyl-cyclohex-2,5-dien-1-one

2-methyl-3-phenyl-4-chloro-3-cyclobutenone

tri-n-butyl(vinyl)tin

2-methyl-[1,1′-biphenyl]-3-amine