4-CHLORO-2-METHYL-3-PHENYLCYCLOBUT-2-EN-1-ONE

Base Information

Chemical Name:4-CHLORO-2-METHYL-3-PHENYLCYCLOBUT-2-EN-1-ONE
CAS No.:16547-35-6
Molecular Formula:C11H9ClO
Molecular Weight:192.645
Hs Code.:
Mol file:16547-35-6.mol

Synonyms:2-Chlor-3-phenyl-4-methyl-cyclobuten-(3)-on;4-Chloro-2-methyl-3-phenyl-2-cyclobutenone;

Suppliers and Price of 4-CHLORO-2-METHYL-3-PHENYLCYCLOBUT-2-EN-1-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-CHLORO-2-METHYL-3-PHENYLCYCLOBUT-2-EN-1-ONE

Chemical Property:

PSA：17.07000
LogP:2.65020

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2-METHYL-3-PHENYLCYCLOBUT-2-EN-1-ONE

There total 9 articles about 4-CHLORO-2-METHYL-3-PHENYLCYCLOBUT-2-EN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 138151-79-8
2-hydroxy-4-methyl-3-phenyl-3-cyclobutenone

: 16547-35-6
2-methyl-3-phenyl-4-chloro-3-cyclobutenone

Guidance literature:: With tetrachloromethane; triphenylphosphine; In acetonitrile; for 0.5h;
DOI:10.1021/ja00030a043

Reference yield: 41.0%

: 673-32-5
1-Phenylprop-1-yne

: 79-36-7
dichloroacethyl chloride

: 16547-35-6
2-methyl-3-phenyl-4-chloro-3-cyclobutenone

Guidance literature:: With copper; zinc; In 1,2-dimethoxyethane; diethyl ether; for 48h;
DOI:10.1021/jo00104a033

Reference yield:

: 128242-44-4
3-(1-methylethoxy)-4-phenyl-3-cyclobutene-1,2-dione 2-ethylene acetal

: 16547-35-6
2-methyl-3-phenyl-4-chloro-3-cyclobutenone

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / tetrahydrofuran; hexane / 1 h / -78 °C

2: 78 percent / 10percent aq. HCl / tetrahydrofuran / 0.08 h / Ambient temperature

3: 60 percent / DIBAL / diethyl ether; toluene / 0.5 h / 0 °C

4: 84 percent / 10percent aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature

5: 82 percent / triphenylphosphine, CCl₄ / acetonitrile / 0.5 h

With hydrogenchloride; tetrachloromethane; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; toluene; acetonitrile;
DOI:10.1021/ja00030a043