6-Chloro-3-methylbenzo[B]thiophene-2-carboxylic acid

Base Information

Chemical Name:6-Chloro-3-methylbenzo[B]thiophene-2-carboxylic acid
CAS No.:66490-32-2
Molecular Formula:C₁₀H₇ClO₂S
Molecular Weight:226.683
Hs Code.:
European Community (EC) Number:888-422-9
DSSTox Substance ID:DTXSID701218875

Synonyms:66490-32-2;6-CHLORO-3-METHYLBENZO[B]THIOPHENE-2-CARBOXYLIC ACID;6-chloro-3-methyl-1-benzothiophene-2-carboxylic acid;6-chloro-3-methylbenzothiophene-2-carboxylic acid;SCHEMBL12153769;DTXSID701218875;MFCD22490519;AKOS024171798;AS-42361;FT-0725411;EN300-7412936;6-CHLORO-3-METHYLBENZO[B]THIOPHENE-2-CARBOXYLICACID

Suppliers and Price of 6-Chloro-3-methylbenzo[B]thiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Chloro-3-methylbenzo[b]thiophene-2-carboxylicacid 95+%
5g
$ 1033.00

Crysdot
6-Chloro-3-methylbenzo[b]thiophene-2-carboxylicacid 95+%
1g
$ 344.00

Chemenu
6-Chloro-3-methylbenzo[b]thiophene-2-carboxylicacid 95%
5g
$ 973.00

Chemenu
6-Chloro-3-methylbenzo[b]thiophene-2-carboxylicacid 95%
1g
$ 324.00

Chemcia Scientific
6-Chloro-3-methyl-benzo[b]thiophene-2-carboxylicacid 95%
1 G
$ 295.00

Alichem
6-Chloro-3-methylbenzo[b]thiophene-2-carboxylicacid
5g
$ 974.48

Total 6 raw suppliers

Chemical Property of 6-Chloro-3-methylbenzo[B]thiophene-2-carboxylic acid

Chemical Property:

PSA：65.54000
LogP:3.56130
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:225.9855283
Heavy Atom Count:14
Complexity:246

Purity/Quality:

98%+ ^*data from raw suppliers

6-Chloro-3-methylbenzo[b]thiophene-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC2=C1C=CC(=C2)Cl)C(=O)O

Technology Process of 6-Chloro-3-methylbenzo[B]thiophene-2-carboxylic acid

There total 4 articles about 6-Chloro-3-methylbenzo[B]thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415968-74-9
methyl 6-chloro-3-methylbenzo[b]thiophene-2-carboxylate

: 66490-32-2
6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;
DOI:10.1021/jm301448p

Reference yield:

: C₁₂H₁₁ClO₂S

: 66490-32-2
6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

: 175711-83-8
4’-chloro-2’-fluoroacetophenone

: 66490-32-2
6-chloro-3-methylbenzo[b]thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 18 h / 0 - 20 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; methanol; water / 4 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/jm301448p