6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Base Information

• Chemical Name: 6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
• CAS No.: 192705-78-5
• Molecular Formula: C15H15N5O2
• Molecular Weight: 297.3119
• Mol file: 192705-78-5.mol

Synonyms:6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Chemical Property of 6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Chemical Property:

• Melting Point: >270°C (dec.)
• PSA: 109.90000
• LogP: 2.38470
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Sparingly)

Purity/Quality:

95% ^*data from raw suppliers

6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Tyrosine Kinase Inhibitors.

Technology Process of 6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

There total 2 articles about 6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,4-diamino-5-pyrimidinecarboxaldehyde (20781-06-0) + 3,5-dimethoxyphenylacetonitrile (13388-75-5) → 6-(3,5-dimethoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (192705-78-5)

Guidance literature:

With sodium hydride; In 2-ethoxy-ethanol; for 4h; Heating;

DOI:10.1021/jm970367n

Reference yield:

→ 6-(3,5-dimethoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (192705-78-5)

Guidance literature:

Reference yield:

4-(diethylamino)butylamine (27431-62-5) + 6-(3,5-dimethoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (192705-78-5) → N2-[4-(diethylamino)butyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine (862370-79-4)

Guidance literature:

With aminosulfonic acid; at 140 - 180 ℃;

upstream raw materials:

2,4-diamino-5-pyrimidinecarboxaldehyde

3,5-dimethoxyphenylacetonitrile

Downstream raw materials:

N²-[4-(diethylamino)butyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

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