3,5-DIMETHOXYPHENYLACETONITRILE

Base Information

• Chemical Name: 3,5-DIMETHOXYPHENYLACETONITRILE
• CAS No.: 13388-75-5
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Hs Code.: 29269090
• Mol file: 13388-75-5.mol

Synonyms:Acetonitrile,(3,5-dimethoxyphenyl)- (7CI,8CI);(3,5-Dimethoxyphenyl)acetonitrile;NSC 245126;

Chemical Property of 3,5-DIMETHOXYPHENYLACETONITRILE

Chemical Property:

• Appearance/Colour: Yellow solid
• Vapor Pressure: 0.000404mmHg at 25°C
• Melting Point: 54-57 °C(lit.)
• Refractive Index: 1.511
• Boiling Point: 316.676 °C at 760 mmHg
• Flash Point: 127.256 °C
• PSA: 42.25000
• Density: 1.083 g/cm³
• LogP: 1.76988
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(3,5-Dimethoxyphenyl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,T
• Hazard Codes: Xn,T
• Statements: 22
• Safety Statements: 36/37-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: (3,5-Dimethoxyphenyl)acetonitrile (cas# 13388-75-5) is a compound useful in organic synthesis.

Technology Process of 3,5-DIMETHOXYPHENYLACETONITRILE

There total 13 articles about 3,5-DIMETHOXYPHENYLACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-dimethoxybenzyl bromide (877-88-3) + sodium cyanide (143-33-9,25596-52-5) → 3,5-dimethoxyphenylacetonitrile (13388-75-5)

Guidance literature:

In dimethyl sulfoxide; at 35 - 40 ℃; for 1.5h;

Reference yield: 95.0%

3,5-dimethoxybenzylchloride (6652-32-0) + sodium cyanide (143-33-9,25596-52-5) → 3,5-dimethoxyphenylacetonitrile (13388-75-5)

Guidance literature:

In dimethyl sulfoxide; for 4h;

DOI:10.1080/00304949609356528

Reference yield: 85.0%

1-Bromo-2,4-dimethoxybenzene (17715-69-4) + acetonitrile (75-05-8,26809-02-9) → 3,5-dimethoxyphenylacetonitrile (13388-75-5)

Guidance literature:

With ethoxyethoxyethanol; sodium amide; In 1,2-dimethoxyethane; 1.) 45 deg C, 2 h, 2.) -10 deg C, 2 h, 3.) -20 deg C, 18 h;

upstream raw materials:

3,5-dimethoxybenzylchloride

sodium cyanide

1-Bromo-2,4-dimethoxybenzene

acetonitrile

Downstream raw materials:

2-(3,5-dimethoxy-phenyl)-acetoacetonitrile

α-isopropyl-3,5-dimethoxyphenylacetonitrile

(3,5-dimethoxy-phenyl)-acetic acid ethyl ester

6-(3,5-dimethoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine