7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

Base Information

Chemical Name:7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
CAS No.:1118507-77-9
Molecular Formula:C18H19NO3S
Molecular Weight:329.42
Hs Code.:
Mol file:1118507-77-9.mol

Synonyms:7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;1,2,3,4-Tetrahydro-7-methyl-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one

Suppliers and Price of 7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 95+%
1g
$ 698.00

Chemenu
7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 95%
1g
$ 660.00

Alichem
7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
1g
$ 556.64

Total 5 raw suppliers

Chemical Property of 7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

Chemical Property:

PSA：62.83000
LogP:4.62100

Purity/Quality:

97% ^*data from raw suppliers

7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one

There total 7 articles about 7-Methyl-1-tosyl-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1118507-72-4
7-methyl-1-toluenesulfonyl-2,3,4,5-tetrahydro-1H-1-benzazepine

: 1118507-77-9
7-methyl-1-toluenesulfonyl-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With Celite; pyridinium chlorochromate; In benzene; for 24h; Reflux;
DOI:10.1055/s-0028-1087298

Reference yield:

: 5-hydroxy-4-methoxycarbonyl-7-methyl-1-(p-toluenesulfonyl)-2,3-dihydro-1H-1-benzazepine

: 1118507-77-9
7-methyl-1-toluenesulfonyl-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With water; In dimethyl sulfoxide; at 125 ℃;

Reference yield:

: 3113-72-2
5-methyl-2-nitrobenzoic acid

: 1118507-77-9
7-methyl-1-toluenesulfonyl-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 48 h / -20 °C / Heating / reflux

2: hydrogen / 5% palladium-on-charcoal / ethyl acetate / 8 h

3: pyridine / 0 - 20 °C

4: potassium carbonate / DMF (N,N-dimethyl-formamide) / 80 °C

5: sodium hydride / tetrahydrofuran; DMF (N,N-dimethyl-formamide) / 1.5 h / 0 - 20 °C

6: water / dimethyl sulfoxide / 125 °C

With pyridine; thionyl chloride; water; hydrogen; sodium hydride; potassium carbonate; 5% palladium-on-charcoal; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dimethyl sulfoxide; ethyl acetate;