Methyl 2-amino-5-methylbenzoate

Base Information

• Chemical Name: Methyl 2-amino-5-methylbenzoate
• CAS No.: 18595-16-9
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2922499990
• European Community (EC) Number: 808-146-4
• DSSTox Substance ID: DTXSID60360874
• Nikkaji Number: J82.777K
• Wikidata: Q72487072
• Mol file: 18595-16-9.mol

Synonyms:methyl 2-amino-5-methylbenzoate;18595-16-9;2-amino-5-methylbenzoic acid methyl ester;METHYL2-AMINO-5-METHYLBENZOATE;Benzoic acid, 2-amino-5-methyl-, methyl ester;MFCD00661547;Methyl 6-Amino-m-toluate;Methyl 5-Methylanthranilate;SCHEMBL1129416;4-amino-3-methoxycarbonyltoluene;DTXSID60360874;methyl 2-azanyl-5-methyl-benzoate;BCP24520;6-Amino-m-toluic Acid Methyl Ester;5-Methylanthranilic Acid Methyl Ester;AKOS002665765;AM83180;CS-W002654;SB76298;SY025953;TS-02208;2-amino-5-methyl-benzoic acid methyl ester;FT-0671465;M2541;EN300-42954;A806748;A852064;J-011927;BENZOICACID, 2-AMINO-5-METHYL-, METHYL ESTER;Z111833736

Chemical Property of Methyl 2-amino-5-methylbenzoate

Chemical Property:

• Appearance/Colour: Yellow solid
• Vapor Pressure: 0.00646mmHg at 25°C
• Melting Point: 54-56 °C
• Refractive Index: 1.558
• Boiling Point: 271.4 °C at 760 mmHg
• Flash Point: 132.1 °C
• PSA: 52.32000
• Density: 1.132 g/cm³
• LogP: 1.94500
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

97% ^*data from raw suppliers

Methyl 2-Amino-5-methylbenzoate >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)N)C(=O)OC
• Uses: METHYL 2-AMINO-5-METHYLBENZOATE is a useful synthetic intermediate A useful synthetic intermediate.

Technology Process of Methyl 2-amino-5-methylbenzoate

There total 13 articles about Methyl 2-amino-5-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-Amino-5-methylbenzoic acid (2941-78-8) → 2-amino-5-methylbenzoic acid methyl ester (18595-16-9)

Guidance literature:

With sulfuric acid; for 72h; Reflux;

DOI:10.1039/c7ob00006e

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-Amino-5-methylbenzoic acid (2941-78-8) → 2-amino-5-methylbenzoic acid methyl ester (18595-16-9)

Guidance literature:

In diethyl ether; for 1h; Inert atmosphere;

DOI:10.1021/jo1016713

Reference yield: 99.0%

5-methyl-2-nitro-benzoic acid methyl ester (20587-30-8) → 2-amino-5-methylbenzoic acid methyl ester (18595-16-9)

Guidance literature:

With 5 mol% Pd/C; hydrogen; DavePhos; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1039/c8dt04938f

upstream raw materials:

methanol

6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

5-methyl-2-nitro-benzoic acid methyl ester

2-Amino-5-methylbenzoic acid

Downstream raw materials:

6-methyl-2-phenylquinazolin-4(3H)-one

2,8-dimethyl-5H,11H-dibenzo[b,f][1,5]diazocine-6,12-dione

methyl 5-methyl-2-[(trifluoromethyl)sulfonylamino]benzoate

2-(2-Carboxy-phenylamino)-5-methyl-benzoic acid methyl ester