2-BROMO-5-NITROTHIOANISOLE

Base Information

• Chemical Name: 2-BROMO-5-NITROTHIOANISOLE
• CAS No.: 1003709-83-8
• Molecular Formula: C₇H₆BrNO₂S
• Molecular Weight: 248.1
• Mol file: 1003709-83-8.mol

Synonyms:2-BROMO-5-NITROTHIOANISOLE

Chemical Property of 2-BROMO-5-NITROTHIOANISOLE

Chemical Property:

• PSA: 71.12000
• LogP: 3.60240

Purity/Quality:

98% ^*data from raw suppliers

2-BROMO-5-NITROTHIOANISOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-NITROTHIOANISOLE

There total 4 articles about 2-BROMO-5-NITROTHIOANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C6H3BrNO2S(1-)*Na(1+) + dimethyl sulfate (77-78-1) → (2-bromo-5-nitrophenyl)(methyl)sulfane (1003709-83-8)

Guidance literature:

at 0 - 20 ℃; for 1h;

DOI:10.1016/j.tet.2018.08.043

Reference yield:

2-bromo 5-nitroaniline (10403-47-1) → (2-bromo-5-nitrophenyl)(methyl)sulfane (1003709-83-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 1 h / 0 - 5 °C

3.1: 1 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; sodium hydroxide; sodium nitrite; In methanol; water; 1.2: |Sandmeyer Reaction;

DOI:10.1016/j.tet.2018.08.043

Reference yield:

1-bromo-4-nitro-2-thiocyanatobenzene → (2-bromo-5-nitrophenyl)(methyl)sulfane (1003709-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; sodium tetrahydroborate / water; methanol / 1 h / 0 - 5 °C

2: 1 h / 0 - 20 °C

With sodium tetrahydroborate; sodium hydroxide; In methanol; water;

DOI:10.1016/j.tet.2018.08.043

upstream raw materials:

methanol

C₁₂H₆Br₂N₂O₄S₂

dimethyl sulfate

2-bromo 5-nitroaniline

Refernces