BOC-L-2-AMINO-5-METHYLHEX-4-ENOIC ACID

Base Information

• Chemical Name: BOC-L-2-AMINO-5-METHYLHEX-4-ENOIC ACID
• CAS No.: 123098-61-3
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.303
• Mol file: 123098-61-3.mol

Synonyms:BOC-L-2-AMINO-5-METHYLHEX-4-ENOIC ACID;Boc-(S)-2-AMino-5-Methylhex-4-enoic acid

Chemical Property of BOC-L-2-AMINO-5-METHYLHEX-4-ENOIC ACID

Chemical Property:

• Boiling Point: 380.8±35.0 °C(Predicted)
• PKA: 3.93±0.10(Predicted)
• PSA: 75.63000
• Density: 1.070±0.06 g/cm3(Predicted)
• LogP: 2.71150

Purity/Quality:

98.5% ^*data from raw suppliers

BOC-(S)-2-AMINO-5-METHYLHEX-4-ENOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-L-2-AMINO-5-METHYLHEX-4-ENOIC ACID

There total 5 articles about BOC-L-2-AMINO-5-METHYLHEX-4-ENOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(3S,5S,6R)-4-(tert-butyloxycarbonyl)-5,6-diphenyl-3-(3'-methyl-2'-butenyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one (123098-56-6) → (S)-N-(tert-butyloxycarbonyl)dimethallylglycine (123098-61-3)

Guidance literature:

With ammonia; lithium; In tetrahydrofuran; ethanol;

DOI:10.1016/S0040-4039(00)82268-6

Reference yield:

tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate (112741-49-8,173397-90-5) → (S)-N-(tert-butyloxycarbonyl)dimethallylglycine (123098-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2: 52 percent / Li, NH₃(liquid), ethanol / tetrahydrofuran / 1 h / -33 °C

With ethanol; ammonia; sodium hexamethyldisilazane; lithium; In tetrahydrofuran;

DOI:10.1021/ja00024a038

Reference yield:

prenyl bromide (870-63-3) → (S)-N-(tert-butyloxycarbonyl)dimethallylglycine (123098-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 1 h / -78 °C

2: 52 percent / Li, NH₃(liquid), ethanol / tetrahydrofuran / 1 h / -33 °C

With ethanol; ammonia; sodium hexamethyldisilazane; lithium; In tetrahydrofuran;

DOI:10.1021/ja00024a038

upstream raw materials:

(3S,5S,6R)-4-(tert-butyloxycarbonyl)-5,6-diphenyl-3-(3'-methyl-2'-butenyl)-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

2-methyl-but-2-ene

(2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid

isobutene