4-MERCAPTOCINNAMIC ACID

Base Information

• Chemical Name: 4-MERCAPTOCINNAMIC ACID
• CAS No.: 28995-22-4
• Molecular Formula: C9H8O2S
• Molecular Weight: 180.227
• Hs Code.: 2930909090
• Mol file: 28995-22-4.mol

Synonyms:4-MERCAPTOCINNAMIC ACID;3-(4-Mercaptophenyl)-2-propenoic Acid;p-Mercapto-cinnaMic Acid;3-(4-Mercaptophenyl)acrylic acid;28995-22-4

Chemical Property of 4-MERCAPTOCINNAMIC ACID

Chemical Property:

• Melting Point: 217-218°C
• PSA: 76.10000
• LogP: 2.07310
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-MercaptocinnamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Mercaptocinnamic Acid (cas# 28995-22-4) is a compound useful in organic synthesis.

Technology Process of 4-MERCAPTOCINNAMIC ACID

There total 5 articles about 4-MERCAPTOCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-chlorosulfonyl-cinnamic acid (17641-30-4) → C9H8O2S (28995-22-4,155378-75-9)

Guidance literature:

With triphenylphosphine; In toluene; for 0.166667h; chemoselective reaction; Inert atmosphere;

DOI:10.1055/s-0029-1216955

Reference yield: 60.0%

(2E)-3-[4-(chlorosulfonyl)phenyl]prop-2-enoic acid (155378-73-7) + ethanol (64-17-5) → 4-mercapto-trans-cinnamic acid (28995-22-4,155378-75-9)

Guidance literature:

With stannous chloride; In hydrogenchloride; sodium hydroxide; water;

Reference yield:

(2E)-3-[4-(chlorosulfonyl)phenyl]prop-2-enoic acid (155378-73-7) → 4-mercapto-trans-cinnamic acid (28995-22-4,155378-75-9)

Guidance literature:

With hydrogenchloride; stannous chloride dihydrate; acetic acid; In water; at 20 - 70 ℃; for 2h;

DOI:10.3184/030823408X347576

upstream raw materials:

(2E)-3-[4-(chlorosulfonyl)phenyl]prop-2-enoic acid

ethanol

4-chlorosulfonyl-cinnamic acid

Downstream raw materials:

trans-4-(n-butylthio)cinnamic acid

(E)-3-<4-(methylthio)phenyl>propenoic acid

4.4'-Dithio-bis-trans-zimtsaeure

4-acetylsulfanyl-trans-cinnamic acid