3-fluoro-4-isopropoxybenzenaMine

Base Information

• Chemical Name: 3-fluoro-4-isopropoxybenzenaMine
• CAS No.: 97566-69-3
• Molecular Formula: C₉H₁₂FNO
• Molecular Weight: 169.199
• Mol file: 97566-69-3.mol

Synonyms:3-fluoro-4-isopropoxybenzenaMine

Chemical Property of 3-fluoro-4-isopropoxybenzenaMine

Chemical Property:

• Boiling Point: 266.2±20.0 °C(Predicted)
• PKA: 5.13±0.10(Predicted)
• PSA: 35.25000
• Density: 1.103±0.06 g/cm3(Predicted)
• LogP: 2.77630

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoro-4-isopropoxybenzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-fluoro-4-isopropoxybenzenaMine

There total 2 articles about 3-fluoro-4-isopropoxybenzenaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-1-isopropoxy-4-nitrobenzene (951317-39-8) → 3-fluoro-4-isopropoxyaniline (97566-69-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 1h; under 1810.07 Torr;

Reference yield:

2-fluoro-4-nitrophenol (403-19-0) → 3-fluoro-4-isopropoxyaniline (97566-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 8 h / 20 - 45 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 1810.07 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;

Reference yield:

3-fluoro-4-isopropoxyaniline (97566-69-3) → methyl 6-cyano-2-((3-fluoro-4-isopropoxyphenyl)-(isopropyl)amino)-1H-indole-3-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 12 h / 20 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide / dichloromethane / 2 h / 0 °C

2.2: 2 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; N-chloro-succinimide; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;

upstream raw materials:

2-fluoro-4-nitrophenol

2-fluoro-1-isopropoxy-4-nitrobenzene

Downstream raw materials:

1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylimino)-3-(2-hydroxycarbonyl-2-methoxyiminoethyl)-1,3,5-triazinane-2,4-dion

1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-3-(2-pyridylmethyl)-1,3,5-triazine-2,4(1H,3H)-dion

1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylimino)-3-(6-oxo-1,6-dihydro-3-pyridyl)methyl-1,3,5-triazinane-2,4-dion

1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one