1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

Base Information

Chemical Name:1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one
CAS No.:1239685-49-4
Molecular Formula:C₂₁H₂₂ClFN₄O₄
Molecular Weight:448.881
Hs Code.:

Synonyms:1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

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Chemical Property of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

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Technology Process of 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

There total 5 articles about 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1239691-19-0
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-(tetrahydro-2H-pyrane-2-yloxy)ethoxy)-1,3,5-triazine-2(1H)-one

: 1239685-49-4
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

Guidance literature:: 1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-(tetrahydro-2H-pyrane-2-yloxy)ethoxy)-1,3,5-triazine-2(1H)-one; With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; water;

Reference yield:

: 1239685-40-5
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-1,3,5-triazine-2,4(1H,3H)-dion

: 1239685-49-4
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

1.2: 5 h / 20 °C / Cooling with ice

2.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; mineral oil;

Reference yield:

: 24827-37-0
N-(4-chlorobenzyl)thiourea

: 1239685-49-4
1-(4-chlorobenzyl)-6-(3-fluoro-4-isopropoxyphenylamino)-4-(2-hydroxyethoxy)-1,3,5-triazine-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 5 h / 20 °C / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: acetic acid / tert-butyl alcohol / 8 h / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

3.2: 5 h / 20 °C / Cooling with ice

4.1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; mineral oil; tert-butyl alcohol;